| Grant number: | 14/24475-0 |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| Start date: | February 01, 2015 |
| End date: | May 31, 2018 |
| Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
| Principal Investigator: | Giselle Cerchiaro |
| Grantee: | Emilene Arusievicz Nunes |
| Host Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
Abstract Much is known about the oxidation of biomolecules and their relationship to Reactive Oxygen Species (ROS) and intracellular redox imbalance systems. However, little is known regarding the transition metals present in trace amounts (such as copper, iron and zinc) and their engagement in this type of oxidation mechanism. Our research group has actively contributed to the elucidation of the role of trace metals in biological environment, but this seemingly simple question - their involvement and their enzymes, such as Cu, Zn-superoxide dismutase (SOD1) - and redox imbalance in neurodegeneeration is still unclear. This project will try to elucidate some of these issues, involving the homeostasis of copper and zinc (SOD1 enzyme constituents) and comparing to treatment with chelating agents and proteins involved in neurodegeneration (±²-amyloid), their interactions in igniting the oxidative damage, DNA damage and cell death, as well as the signaling mechanisms of these processes. Such way is to establish a molecular mechanism for the relationship between zinc, copper, ROS and cell neurodegeneration. (AU) | |
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