The lactate effect on neuroendocrine regulation of somatotropic axis

• Grant number: 14/22934-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2015
• End date: May 31, 2018
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Maria Tereza Nunes
• Grantee: Rafael Barrera Salgueiro
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 16/22525-6 - EFFECT OF LACTATE ON SOMATOTROPIC AXIS ACTIVITY AND ENERGETIC BALANCE. A STUDY IN MCT1-KO MICE AND IN HYPOTHALAMIC PRIMARY CULTURES., BE.EP.DR

Abstract

Lactate is the product of the reduction of pyruvate, important reaction for controlling the intracellular pH and the redox state of the cell in which it is produced. When this metabolite is released into the blood stream and diffuses to tissues expressing their transporters, it exerts various physiological roles, such as providing a rich source of carbon for hepatic gluconeogenesis and mitochondrial energy synthesis. Blood lactate also promotes elevated synthesis/secretion of growth hormone (GH), showing a significant activation of the somatotropic axis by an action in which had not yet been identified. We intend to explore potential hypothalamic hormones that are implicated in this regulation and/or highlight a possible direct action of lactate on the synthesis/secretion of GH. For this, we evaluate the gene expression of hypothalamic hormones (GHRH, somatostatin and ghrelin), which are the major hormone involved in the expression of GH and furthermore analyze the lactate directly stimulate the pituitary gland to increase expression of GH. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CALIL-SILVEIRA, JAMILE; SERRANO-NASCIMENTO, CAROLINE; LACONCA, RAQUEL CARDOSO; SCHMIEDECKE, LETICIA; SALGUEIRO, RAFAEL BARRERA; KONDO, AYRTON KIMIDI; NUNES, MARIA TEREZA. Underlying Mechanisms of Pituitary-Thyroid Axis Function Disruption by Chronic Iodine Excess in Rats. THYROID, v. 26, n. 10, p. 1488-1498, OCT 2016. (14/22934-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SALGUEIRO, Rafael Barrera. The role of lactate on the neuroendocrine regulation of the somatototropic axis.. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.