Advanced search
Start date
Betweenand

Determination of plasma phospholipids in neuropsychiatric disorders

Grant number: 14/20913-3
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2015
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Medicine - Psychiatry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Wagner Farid Gattaz
Grantee:Alana Caroline Costa
Home Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Phospholipids and related molecules comprise 60% of the nonaqueous portion of the brain and an even larger proportion of dendrites and synapses; they are the major constituents of membrane of neuronal and glial cells of the synaptic vesicle membrane, nuclear endoplasmic reticulum membranes of mitochondria and Golgi complex. The phospholipids are essential for all living cells and therefore changes in metabolism might influence the organism. It is known that changes in metabolism of phospholipids are involved in several neuropsychiatric disorders including Alzheimer's disease, schizophrenia and bipolar disorder. However, these changes appear to be distinct in each neuropsychiatric disease. Determining changes in the composition of plasma phospholipids in each of these diseases, may help to elucidate the pathophysiological mechanisms, and also in the search for candidates of specific biomarkers. For this, chromatography coupled to mass spectrometry is a good method since it provides a comprehensive profile of the substances being studied. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOAQUIM, HELENA P. G.; COSTA, ALANA C.; TALIB, LEDA L.; DETHLOFF, FREDERIK; SERPA, MAURICIO H.; ZANETTI, V, MARCUS; VAN DE BILT, MARTINUS; TURCK, CHRISTOPH W. Plasma Metabolite Profiles in First Episode Psychosis: Exploring Symptoms Heterogeneity/Severity in Schizophrenia and Bipolar Disorder Cohorts. FRONTIERS IN PSYCHIATRY, v. 11, JUN 5 2020. Web of Science Citations: 0.
COSTA, ALANA C.; JOAQUIM, HELENA P. G.; FORLENZA, V, ORESTES; GATTAZ, WAGNER F.; TALIB, LEDA L. Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer's disease: a pilot study. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 270, n. 4, p. 483-488, JUN 2020. Web of Science Citations: 0.
JOAQUIM, HELENA P. G.; COSTA, ALANA CAROLINE; SERPA, MAURICIO HENRIQUES; TALIB, LEDA L.; GATTAZ, WAGNER F. Reduced Annexin A3 in schizophrenia. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v. 270, n. 4, p. 489-494, JUN 2020. Web of Science Citations: 0.
GONCALVES DE FREITAS PEREIRA, MARTA LUISA; DE ARRUDA CAMARGO, MARINA VON ZUBEN; RIBEIRO BELLAN, ARIELLA FORNACHARI; TAHIRA, ANA CAROLINA; DOS SANTOS, BERNARDO; DOS SANTOS, JESSICA; MACHADO-LIMA, ARIANE; NUNES, FATIMA L. S.; FORLENZA, ORESTES VICENTE. Visual Search Efficiency in Mild Cognitive Impairment and Alzheimer's Disease: An Eye Movement Study. JOURNAL OF ALZHEIMER'S DISEASE, v. 75, n. 1, p. 261-275, 2020. Web of Science Citations: 0.
COSTA, ALANA C.; JOAQUIM, HELENA P. G.; FORLENZA, ORESTES; TALIB, LEDA L.; GATTAZ, WAGNER F. Plasma lipids metabolism in mild cognitive impairment and Alzheimer's disease. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 20, n. 3, p. 190-196, MAR 16 2019. Web of Science Citations: 1.
HELENA P. G. JOAQUIM; ALANA C. COSTA; ORESTES V. FORLENZA; WAGNER F. GATTAZ; LEDA L. TALIB. Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients. ARCHIVES OF CLINICAL PSYCHIATRY, v. 46, n. 5, p. 120-124, Out. 2019. Web of Science Citations: 0.
JOAQUIM, HELENA P. G.; COSTA, ALANA C.; GATTAZ, WAGNER F.; TALIB, LEDA LEME. Kynurenine is correlated with IL-1 beta in plasma of schizophrenia patients. JOURNAL OF NEURAL TRANSMISSION, v. 125, n. 5, SI, p. 869-873, MAY 2018. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.