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Metabolomics and evolution of chemical characters in the subtribe Espeletiinae (Asteraceae)

Grant number: 14/17702-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2015
Effective date (End): December 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fernando Batista da Costa
Grantee:Guillermo Federico Padilla Gonzalez
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/21183-4 - Metabolic fingerprinting and biosynthesis of sesquiterpene lactones in Smallanthus sonchifolius and Espeletia (Asteraceae): a metabolomic and transcriptomic approach, BE.EP.DR


The northern region of the tropical Andes in South America was subjected to a series of climate fluctuations as a consequence of the recurrent periods of glaciations and inter-glaciations that occurred in the late Pliocene and early Pleistocene, two to five million years ago. This led to the development of a new ecosystem called páramo, which combines the isothermal climatic conditions of the tropical region with the low temperatures characteristic of high elevations. This ecosystem is characterized by a series of climatic and vegetation conditions that make it unique, among which stand out the "Frailejones", a group of ca. 143 species grouped in eight genera that make up the subtribe Espeletiinae (Asteraceae, Millerieae). Due to its high morphological variability and recent speciation, the Frailejones are considered a classic example for studying rapid adaptive radiations and speciation mechanisms in plants. Therefore, the biology, ecology and especially the phylogeny and taxonomy of this group have been the focus of numerous studies in recent years. However, chemically have been poorly studied and there are still many questions concerning the possible correlation between the chemical composition of the subtribe and their taxonomy, morphology, and biogeography. Furthermore, it is unknown if the evolution of chemical characters in this group may help explain its adaptive evolutionary success, considering that recent studies have shown that the chemical composition of the species of the main genus in the subtribe (Espeletia) varies according to their geographical origin, with similar results based on molecular markers. Therefore, this research project aims to investigate species of Espeletiinae through a metabolomic approach by UHPLC-UV-MS and multivariate statistical methods, in order to contribute to the understanding of the secondary metabolism chemistry of this subtribe and its correlation with biological data. Additionally, we intend to perform phylogenetic analyzes with sequences from the literature with the aim of mapping the chemical characters in the evolution of the subtribe and thus determine ancestral states, contributing to the understanding of evolutionary processes that have shaped the current distribution and diversity of secondary metabolites in Espeletiinae. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PADILLA-GONZALEZ, GUILLERMO F.; DIAZGRANADOS, MAURICIO; OLIVEIRA, TIAGO B.; CHAGAS-PAULA, DANIELA A.; DA COSTA, FERNANDO B.. Chemistry of the subtribe Espeletiinae (Asteraceae) and its correlation with phylogenetic data: an in silico chemosystematic approach. Botanical Journal of the Linnean Society, v. 186, n. 1, p. 18-46, . (14/17702-0)
PADILLA-GONZALEZ, GUILLERMO F.; AMREHN, EVELYN; FREY, MAXIMILIAN; GOMEZ-ZELEDON, JAVIER; KAA, ALEVTINA; DA COSTA, FERNANDO B.; SPRING, OTMAR. Metabolomic and Gene Expression Studies Reveal the Diversity, Distribution and Spatial Regulation of the Specialized Metabolism of Yacon (Smallanthus sonchifolius, Asteraceae). INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 12, . (14/26866-7, 14/17702-0, 16/21183-4)
ZIAROVSKA, JANA; PADILLA-GONZALEZ, GUILLERMO F.; VIEHMANNOVA, IVA; FERNANDEZ, ELOY. Genetic and chemical diversity among yacon [Smallanthus sonchifolius (Poepp. et Endl.) H. Robinson] accessions based on iPBS markers and metabolomic fingerprinting. Plant Physiology and Biochemistry, v. 141, p. 183-192, . (14/17702-0, 14/26866-7, 16/21183-4)
PADILLA-GONZALEZ, GUILLERMO F.; DIAZGRANADOS, MAURICIO; CCANA-CCAPATINTA, GARI; CASOTI, ROSANA; DA COSTA, FERNANDO B.. Caffeic acid derivatives and further compounds from Espeletia barclayana Cuatrec. (Asteraceae, Espeletiinae). Biochemical Systematics and Ecology, v. 70, p. 291-293, . (14/17702-0, 14/26866-7)
PADILLA-GONZALEZ, GUILLERMO FEDERICO; DOS SANTOS, FELIPE ANTUNES; DA COSTA, FERNANDO BATISTA. Sesquiterpene Lactones: More Than Protective Plant Compounds With High Toxicity. CRITICAL REVIEWS IN PLANT SCIENCES, v. 35, n. 1, p. 18-37, . (12/10249-3, 14/17702-0, 10/51454-3)
PADILLA-GONZALEZ, GUILLERMO F.; DIAZGRANADOS, MAURICIO; DA COSTA, FERNANDO B.. Biogeography shaped the metabolome of the genus Espeletia: a phytochemical perspective on an Andean adaptive radiation. SCIENTIFIC REPORTS, v. 7, . (14/17702-0, 14/26866-7, 10/51454-3)
PADILLA-GONZALEZ, GUILLERMO E.; DIAZGRANADOS, MAURICIO; DA COSTA, FERNANDO B.. Effect of the Andean Geography and Climate on the Specialized Metabolism of Its Vegetation: The Subtribe Espeletiinae (Asteraceae) as a Case Example. METABOLITES, v. 11, n. 4, . (16/21183-4, 14/17702-0, 14/26866-7, 10/51454-3)
GUILLERMO F. PADILLA-GONZÁLEZ; JENNYFER A. ALDANA; FERNANDO B. DA COSTA. Chemical characterization of two morphologically related Espeletia (Asteraceae) species and chemometric analysis based on essential oil components. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 26, n. 6, p. 694-700, . (14/17702-0)
PADILLA-GONZALEZ, GUILLERMO F.; FREY, MAXIMILIAN; GOMEZ-ZELEDON, JAVIER; DA COSTA, FERNANDO B.; SPRING, OTMAR. Metabolomic and gene expression approaches reveal the developmental and environmental regulation of the secondary metabolism of yacon (Smallanthus sonchifolius, Asteraceae). SCIENTIFIC REPORTS, v. 9, . (14/26866-7, 16/21183-4, 14/17702-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GONZALEZ, Guillermo Federico Padilla. Metabolomics and evolution of chemical traits in the subtribe Espeletiinae (Asteraceae). 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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