Bioglass/colagen scaffolds enriched with mesenchymal stem cell: effects on the repair of critical defects in rat calvaria

• Grant number: 14/23471-1
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date until: April 01, 2015
• End date until: June 30, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Claudia Muniz Renno
• Grantee: Hueliton Wilian Kido
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
• Associated scholarship(s): 15/21071-9 - Polycaprolactone/Biosilicate® membranes for guided bone tissue regeneration, BE.EP.PD

Abstract

Fractures difficult consolidation and large bone defects are associated with a substantial physical incapacity to the affected individuals and the high socio-economic costs, constituting a major challenge to clinical medicine. Thereby, it is necessary research in regenerative medicine and tissue engineering which aims to develop innovative technologies that promote bone regeneration and accelerate the healing process of the fracture, for use in the health system, in order to reduce costs and reduce the morbidity and mortality related to complications in the consolidation process. Thus, this study aims to evaluate the effects of the bioglass/collagen scaffold enriched with mesenchymal stem cells (MSCs) on bone defect repair process. To achieve this objective, detailed studies will be carried on the effects of the bioglass/collagen scaffolds on the adhesion, proliferation and differentiation of MSCs in vitro and the action of this material in combination with MSCs on tissue regeneration in a model of bone defect in vivo. Given the above, it is expected that the development of this project will result in economic benefits and hence social for the Brazilian population, since the investigation of the effects of the combination of MSCs with bioglass/collagen scaffold on bone tissue may determine the development of more effective and safer treatments, which may result in the use of new technological resources in the health system.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KIDO, HUELITON WILIAN; GABBAI-ARMELIN, PAULO ROBERTO; AVANZI, INGRID REGINA; DA SILVA, ANTONIO CARLOS; FERNANDES, KELLY ROSSETTI; FORTULAN, CARLOS ALBERTO; MUNIZ RENNO, ANA CLAUDIA. Vacuumed collagen-impregnated bioglass scaffolds: Characterization and influence on proliferation and differentiation of bone marrow stromal cells. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 107, n. 2, p. 211-222, FEB 2019. (14/23471-1)

GABBAI-ARMELIN, P. R.; KIDO, H. W.; CRUZ, M. A.; PRADO, J. P. S.; AVANZI, I. R.; CUSTODIO, M. R.; RENNO, A. C. M.; GRANITO, R. N.. Characterization and Cytotoxicity Evaluation of a Marine Sponge Biosilica. MARINE BIOTECHNOLOGY, v. 21, n. 1, p. 65-75, FEB 2019. (14/23471-1, 15/20704-8)

KIDO, H. W.; GABBAI-ARMELIN, P. R.; MAGRI, A. M. P.; FERNANDES, K. R.; CRUZ, M. A.; SANTANA, A. F.; CALIARI, H. M.; PARISI, J. R.; AVANZI, I. R.; DAGUANO, J. K. M. B.; et al. Bioglass/collagen scaffolds combined with bone marrow stromal cells on bone healing in an experimental model in cranial defects in rats. JOURNAL OF BIOMATERIALS APPLICATIONS, v. N/A, p. 13-pg., 2023-03-14. (14/23471-1)