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Influence of caja supplementation on cardiac remodeling induced by cigarette smoke exposure in rats

Grant number: 14/21310-0
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Marcos Ferreira Minicucci
Grantee:Maria Angelica Martins Lourenço
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

According to data from the Ministry of Health, cardiovascular diseases are the most common cause of death in all regions of Brazil, representing 28.6% of the 1,170,498 deaths in 2011. Among them we highlight the coronary arterial diseases and Heart Failure (HF). Among the factors related to the development of HF, the Cardiac Remodeling (CR) process is one of the most important. Recently, Exposure to Cigarette Smoke (ECS) has been investigated in experimental studies and clinical trials, as one of the causes of RC. It is believed that the increased inflammation and oxidative stress are involved in this process. In order to attenuate the CR process induced by ECS, various substances are being studied. Among these substances with anti-inflammatory and antioxidant potential, fruit as cajá is one of the most important. The cajá (Spondias Mombin-SM), is an ovoid fruit characterized by presenting juice sweet/sour, found mainly in the States of north and northeast of Brazil. It is believed that its effects are secondary to phenolics, flavonoids and carotenoids present in fruit. Study that evaluated the administration of cajá before myocardial aggression by isoproterenol observed increased activity of superoxide dismutase and catalase and reduced concentrations of GSH and malondialdehyde. However, the effects of cajá on cardiac remodeling process induced by the ECS has not yet been studied. Thus, we believe that, by their antioxidant and anti-inflammatory effects, SM supplementation can attenuate the CR process induced by ECS. Therefore, the objective of this study is to evaluate the influence of cajá supplementation on cardiac remodeling process induced by ECS in rats. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARTINS LOURENCO, MARIA ANGELICA; BRAZ, MARIANA GOBBO; AUN, ALINE GARCIA; BUZATI PEREIRA, BRUNA LETICIA; FERNANDES, FABIO HENRIQUE; KAZMAREK, ELISA MOYA; BACHIEGA, TATIANA FERNANDA; ZANATI, SILMEIA GARCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; HENRIQUE FERNANDES, ANA ANGELICA; RUPP DE PAIVA, SERGIO ALBERTO; MAMEDE ZORNOFF, LEONARDO ANTONIO; MINICUCCI, MARCOS FERREIRA. Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke. BMC PHARMACOLOGY & TOXICOLOGY, v. 19, NOV 16 2018. Web of Science Citations: 0.
MARTINS LOURENCO, MARIA ANGELICA; BRAZ, MARIANA GOBBO; AUN, ALINE GARCIA; BUZATI PEREIRA, BRUNA LETICIA; FIGUEIREDO, AMANDA MENEZES; CANDIDO DA SILVA, RENATA APARECIDA; KAZMAREK, ELISA MOYA; CORREA ALEGRE, PATRICIA HELENA; BACHIEGA, TATIANA FERNANDA; ZANATI, SILMEIA GARCIA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; HENRIQUE FERNANDES, ANA ANGELICA; RUPP DE PAIVA, SERGIO ALBERTO; MAMEDE ZORNOFF, LEONARDO ANTONIO; MINICUCCI, MARCOS FERREIRA. Spondias mombin supplementation attenuated cardiac remodelling process induced by tobacco smoke. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 22, n. 8, p. 3996-4004, AUG 2018. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOURENÇO, Maria Angelica Martins. Influência da suplementação de cajá no processo de remodelação cardíaca induzido pela exposição à fumaça do cigarro em ratos. 2017. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Medicina..

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