Standardized phytotherapics for the treatment of chronicle diseases: Rhizophora mangle

• Grant number: 14/23951-3
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): April 01, 2015
• Effective date (End): January 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Wagner Vilegas
• Grantee: Leonardo Mendes de Souza Mesquita
• Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil
• Associated research grant: 09/52237-9 - Standardized herbal medicines for the treatment of chronic diseases, AP.BTA.TEM

Abstract

Plant species containing bioactive substances are, increasingly, the object of research, leading to the search for alternative therapeutic or revealing substances that subsequently can be exploited in order to produce drug treatments. So phytochemical analysis studies are of great importance, due to the large number of secondary metabolites that can be found. The study of medicinal plants is vast, and has increasingly attracted the attention of society, being an alternative to the high cost of allopathic source. So for that medicinal plants are used safely, multidisciplinary analysis studies have become increasingly the subject of research in herbal medicine. The National Health Surveillance Agency and the Ministry of Health (ANVISA) recently approved 71 medicinal plants for the use of Brazilians with potential against diabetes, ulcers, sores and other chronic diseases were selected. This is a list that serves to guide research and studies in order to generate products that can be aggregated within the health system. This project will address the chemical and pharmacological study of Rhizophora mangle (popularly known as red mangrove), aims to develop analytical strategies that will allow qualitative and quantitative standardization of a plant extract, including identification of classes of substances, chemical markers, or the active principles. This plant is commonly used by traditional coastal populations, primarily for the treatment of diabetes, hemorrhoids, stomach pain and analgesia. Standardized extracts also allows comparison of the chemical composition of species belonging to the same genus (avoiding duplication / pharmacological phytochemicals efforts) as well as planning for the targeted isolation of potentially unknown substances and the investigation of complex extracts strategies. The most promising extracts are standardized according to international standards. The work is interdisciplinary, with participants from various campuses of UNESP (Araraquara Institute of Chemistry, Faculty of Pharmaceutical Sciences of Araraquara, Institute of Biosciences of Botucatu). (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SOUZA MESQUITA, LEONARDO MENDES; BITTENCOURT RODRIGUES, CAROLINE FABRI; DA ROCHA, CLAUDIA QUINTINO; BIANCHIM, MAYARA SILVEIRA; RODRIGUES, CLENILSON MARTINS; DE OLIVEIRA, VANDA MARIA; GAETA, HENRIQUE HESSEL; BELCHOR, MARIANA NOVO; TOYAMA, MARCOS HIKARI; VILEGAS, WAGNER. LC-ESI-IT-MS/MS and MALDI-TOF Approach: Identification of Natural Polymers from Rhizophora mangle Barks and Determination of Their Analgesic and Anti-inflammatory Properties. NATURAL PRODUCTS AND BIOPROSPECTING, v. 9, n. 1, p. 23-34, FEB 2019. (14/23951-3, 09/52237-9)

DE SOUZA MESQUITA, LEONARDO MENDES; BITTENCOURT RODRIGUES, CAROLINE FABRI; DA ROCHA, CLAUDIA QUINTINO; BIANCHIM, MAYARA SILVEIRA; RODRIGUES, CLENILSON MARTINS; DE OLIVEIRA, VANDA MARIA; GAETA, HENRIQUE HESSEL; BELCHOR, MARIANA NOVO; TOYAMA, MARCOS HIKARI; VILEGAS, WAGNER. LC-ESI-IT-MS/MS and MALDI-TOF Approach: Identification of Natural Polymers from Rhizophora mangle Barks and Determination of Their Analgesic and Anti-inflammatory Properties. NATURAL PRODUCTS AND BIOPROSPECTING, v. 9, n. 1, p. 12-pg., 2019-02-01. (09/52237-9, 14/23951-3)

DE SOUZA MESQUITA, LEONARDO MENDES; RABELO E PAIVA CARIA, CINTIA; SANTOS, PAOLA SOUZA; RUY, CAIO CESAR; LIMA, NATALIA DA SILVA; TAKETA MOREIRA, DEBORA KONO; DA ROCHA, CLAUDIA QUINTINO; MURADOR, DANIELLA CARISA; DE ROSSO, VERIDIANA VERA; GAMBERO, ALESSANDRA; et al. Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice. Molecules, v. 23, n. 9, SEP 2018. (14/23951-3, 09/52237-9)

DE SOUZA MESQUITA, LEONARDO MENDES; CARIA, CINTIA RABELO E PAIVA; SANTOS, PAOLA SOUZA; RUY, CAIO CESAR; LIMA, NATALIA DA SILVA; TAKETA MOREIRA, DEBORA KONO; DA ROCHA, CLAUDIA QUINTINO; MURADOR, DANIELLA CARISA; DE ROSSO, VERIDIANA VERA; GAMBERO, ALESSANDRA; et al. Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice (vol 23, pg 2114, 2018). Molecules, v. 24, n. 1, p. 1-pg., 2019-01-01. (09/52237-9, 14/23951-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MESQUITA, Leonardo Mendes de Souza. Standardized phytotherapics for the treatment of chronicle diseases: Rhizophora mangle. 2017. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. São Vicente São Vicente.