Effectiveness evaluation of a gel with low concentration fluoride supplemented with sodium trimetaphosphate on demineralization enamel dental: study in situ

• Grant number: 15/04041-9
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2015
• Effective date (End): April 30, 2017
• Field of knowledge: Health Sciences - Dentistry - Pediatric Dentistry
• Principal Investigator: Marcelle Danelon
• Grantee: Sara Tiemi Felipe Akabane
• Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The proposal of this study is to evaluate the ability of a topical gel neutral pH highly concentrated fluoride supplemented with sodium trimetaphosphate (TMP) in situ reducing demineralization of the dental enamel. Will be performed 5 experimental periods with duration of seven days each, and washout of 7 days amongst them, one blind, crossover study. Bovine enamel blocks (4 mm x 4 mm; n = 240) are prepared from bovine incisors and selected from the initial surface hardness (SH). Volunteers (n = 12) use intra-oral palatal appliances containing 4 enamel fragments, which will be submitted to the following treatments: 1) Toothpaste Fluoride 1100 µg F/g (DF) (1100); 2) Gel without F/ TMP (Placebo); 3) Gel 4500 µg F/g + 5% TMP (4500 5%TMP); 4) Gel 9000 µg F/g (9000) and 5) Gel 12300 µg F/g (Acid Gel). After topical application of the gel or fluoride toothpaste for 1 minute, 2 blocks are removed for analysis of calcium fluoride concentration formed in the enamel (CaF2) (n = 120). The cariogenic challenge will be produced by 30% sucrose solution, 6x/day. After the experimental period, will be determined the final surface hardness (SH1), percentage of surface hardness change (%SH), hardness in longitudinal section (”KHN) and calcium fluoride content (CaF2), retained on enamel (n = 120). Statistical analysis will be considered as variables the values of %SH, ”KHN and CaF2, formed and retained on enamel and as a variation factor, toothpaste and experimental and commercial gels. A more appropriate statistical test (p <0.05) will be used after analysis of normality and homogeneity of data. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AKABANE, SARA; DELBEM, ALBERTO CARLOS; PESSAN, JULIANO; GARCIA, LUHANA; EMERENCIANO, NAYARA; GONCALVES, DIEGO FELIPE; DANELON, MARCELLE. In situ effect of the combination of fluoridated toothpaste and fluoridated gel containing sodium trimetaphosphate on enamel demineralization. Journal of Dentistry, v. 68, p. 59-65, JAN 2018. Web of Science Citations: 3.