PH monitoring and levels of bone insertion before and after treatment with metronidazole modified release from polymeric bioadhesive systems into periodontal pockets

• Grant number: 14/12035-6
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2015
• Effective date (End): December 31, 2015
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Vinícius Pedrazzi
• Grantee: Lara Osório Costa
• Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The aim of this study is to develop an in vivo evaluation of the pH and also the levels of bone insertion in patients with chronic periodontal disease undergoing conventional periodontal treatment - scaling and root planing (SRP) and devices for metronidazole modified release in films and semi-solid systems (gels) containing microencapsulated metronidazole for the treatment of periodontitis. A clinical trial in humans will be conducted to test the hypothesis that the associated techniques of drug local release systems (film or gel) to scaling and root planing (SRP) is superior to the use SRP therapy alone. 45 patients with chronic periodontitis will be selected and randomly divided into 3 groups of 15 patients each: group 1 - scaling and root planing (SRP) - active control; Group 2 - SRP + metronidazole film; Group 3 - SRP + metronidazole gel. Changes of the periodontal pocket pH will be evaluate at times: (T0) before application of the formulations (films / gels); (T1) immediately after application (5 minutes); (T2) after 1 hour (T3) after 3 days of application. For the level of bone insertion it will be monitored during and after treatment at Time 1) initial (T0 = baseline), 2) after gel / film application (T1); 3) after 1 month (T2 = 1 month), 4) after 3 months (T3 = 3 months) and 5) after 06 months (T4 = 06 months).