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Construction and evaluation of a frequency-domain diffuse optical spectroscopy device for brain monitoring in the clinic

Grant number: 14/25486-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2015
Effective date (End): October 31, 2019
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Rickson Coelho Mesquita
Grantee:Rodrigo Menezes Forti
Home Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID
Associated scholarship(s):16/13139-5 - Development of optical probes and algorithms for neurocritical care monitoring, BE.EP.DR


Diffuse optical spectroscopy (DOS) aims to investigate tissue physiology millimeters to centimeters below the tissue surface. The technique has made significant progress in the past few decades, and it is currently an established imaging technique to probe tissue physiology, particularly in the brain. Despite its potential, DOS has yet not made significant impact as a continuous, bedside monitoring tool in the clinic. The goal of this project is to construct and characterize a portable frequency-domain DOS instrument to provide absolute oxygenation measurements in the clinical setting, in real time. The proposed instrument will be employed in a clinical setting along with a diffuse correlation spectroscopy instrument to provide real time oxygen metabolism in the brain, and its usefulness will be evaluated in the neuro-intensive care unit with traumatic brain injury patients.