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Role of ATP in lateral hypothalamus and perifornical area (LH/PFA) in daily variations of ventilatory responses induced by central chemoreflex

Grant number: 15/07288-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2015
Effective date (End): October 31, 2016
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Mirela Barros Dias
Grantee:Eliandra Nunes da Silva
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:13/04216-8 - Neural mechanisms involved in the diurnal variation of the central chemoreflex control, AP.JP


Introduction: Evidence suggests the existence of daily variations of the control of the central chemoreflex, and has been attributed to orexinergic neurons of the lateral hypothalamus and perifornicial area (LH / PFA ) as a mediator of circadian variations in central chemosensitive function, but the mechanisms involved are poorly understood . Objective: This project aims to investigate the possible role of purinergic neurotransmission in the LH / PFA in the modulation of ventilatory response to hypercapnia in different stages of the sleep-wake cycle and light/dark period. Methods: We will study the effects on ventilation in air and in 7% CO2 of microinjection of ATP in the LH/PFA in Wistar rats during wakefulness and NREM sleep, under dark and light periods. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, ELIANDRA N.; HORTA-JUNIOR, JOSE DE ANCHIETA C.; GARGAGLIONI, LUCIANE H.; DIAS, MIRELA B.. ATP in the lateral hypothalamus/perifornical area enhances the CO2 chemoreflex control of breathing. Experimental Physiology, v. 103, n. 12, p. 1679-1691, . (15/07288-5, 13/04216-8)

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