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Nitric oxide releasing polymeric nanoparticles for topical applications

Grant number: 15/00393-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2015
Effective date (End): March 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Amedea Barozzi Seabra
Grantee:Milena Trevisan Pelegrino
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


Nitric oxide (NO) is a gaseous free-radical, free of charge, with a small size and lipophilic behavior. These characteristics allow NO to spread in biological environment by crossing the physiological barriers and communicating with the cells. Nowadays, researchers demonstrated that de NO is involved in several biological process, such as the dilation of blood vessels, immune responses, inhibition of platelet adhesion and aggregation, among others. Furthermore, NO is a key endogenous molecule, which mediates a wide range of homeostatic functions in human skin, controlling the dermal blood flux, promoting wound healing, controlling skin pigmentation, and protecting the skin against pathogenic agents. Thus, there is a great interest in the development of NO-releasing materials for biomedical applications, in particular, of topical applications. Recently, a strategy which shows potential for enable the therapeutic uses of NO is the combination of nanotechnology with NO donor molecules, such as S-nitrosothiols (RSNOs). In this scenario, the aim of this project is the preparation of polymeric chitosan particles, as vehicles to carry and deliver NO. These particles will be incorporate in polymeric matrices comprised by polyvinyl alcohol film (PVA) and hydrogels of the co-polymer of the commercial brand Pluronic F-127TM. The development of this new nanostructure material involves the synthesis of the particles containing the NO donor, the incorporation of the particles into PVA film and Pluronic F-127TM hydrogels, characterizations of the materials (morphologic and physic-chemistry analysis), kinetics of NO release and evaluation of the materials cytotoxicity. This project is expected to develop new platforms for controlling the release of NO for topical applications. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PELEGRINO, MILENA T.; SILVA, LETECIA C.; WATASHI, CAROLINA M.; HADDAD, PAULA S.; RODRIGUES, TIAGO; SEABRA, AMEDEA B.. Nitric oxide-releasing nanoparticles: synthesis, characterization, and cytotoxicity to tumorigenic cells. JOURNAL OF NANOPARTICLE RESEARCH, v. 19, n. 2, . (16/10347-6, 15/00393-8, 14/13913-7)
PELEGRINO, M. T.; WELLER, R. B.; CHEN, X.; BERNARDES, J. S.; SEABRA, A. B.. Chitosan nanoparticles for nitric oxide delivery in human skin. MedChemComm, v. 8, n. 4, p. 713-719, . (16/10347-6, 15/00393-8)
OLIVEIRA, HALLEY C.; GOMES, BRUNA C. R.; PELEGRINO, MILENA T.; SEABRA, AMEDEA B.. Nitric oxide-releasing chitosan nanoparticles alleviate the effects of salt stress in maize plants. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 61, p. 10-19, . (16/10347-6, 15/00393-8)
PELEGRINO, MILENA T.; DE ARAUJO, DANIELE R.; SEABRA, AMEDEA B.. S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 43, p. 211-220, . (16/10347-6, 15/00393-8, 14/13913-7)
SILVEIRA, NEIDIQUELE M.; SEABRA, AMEDEA B.; MARCOS, FERNANDA C. C.; PELEGRINO, MILENA T.; MACHADO, EDUARDO C.; RIBEIRO, RAFAEL V.. Encapsulation of S-nitrosoglutathione into chitosan nanoparticles improves drought tolerance of sugarcane plants. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 84, p. 38-44, . (16/10347-6, 18/08194-2, 12/19167-0, 15/00393-8)
SILVEIRA, NEIDIQUELE M.; FRUNGILLO, LUCAS; MARCOS, FERNANDA C. C.; PELEGRINO, MILENA T.; MIRANDA, MARCELA T.; SEABRA, AMEDEA B.; SALGADO, IONE; MACHADO, EDUARDO C.; RIBEIRO, RAFAEL V.. Exogenous nitric oxide improves sugarcane growth and photosynthesis under water deficit. PLANTA, v. 244, n. 1, p. 181-190, . (12/19167-0, 15/00393-8)

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Filed patent(s) as a result of this research project

PROCESSOS DE APLICAÇÕES AGRÍCOLAS UTILIZANDO NANOPARTÍCULAS DOADORAS DE ÓXIDO NÍTRICO BR1020160290627 - Universidade Estadual de Londrina (UEL) ; Universidade Federal do ABC (UFABC) . Halley Caixeta de Oliveira ; Amedea Barozzi Seabra ; Bruna Cristina Rodrigues Gomes ; Milena Trevisan Pelegrino - December 2016, 12