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Effect of curcumin on inflammatory and metabolic parameters in obese mice

Grant number: 14/03503-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Camila Renata Corrêa
Grantee:Ângelo Thompson Colombo Lo
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

abstractObesity is a worldwide public health problem , especiallydue to changing eating habits and lack of exercise practicesphysical . The white adipose tissue (WAT ) is an endocrine organ with actionscomplex metabolic , this set of effects leads to comorbidities such asMetabolic syndrome (MS ), which are a set of endocrine factors andMetabolic such as insulin resistance, high blood pressure,hyperglycemia , hypertriglyceridemia and inflammation. Curcumin is a polyphenolnatural origin , is a condiment used in cooking and already own actionantiinflammatory . The objective will be to test whether supplementation withCurcumin is able to reduce the inflammatory profile in adipose tissue andplasma, together with the improvement of the metabolic profile of animals .The animals will be initially divided randomly into two groups( n = 30 animals / group ) to receive standard diet ( P ) + water or standard dietWater + 30% fructose (PF) for 15 weeks . After this period the animalswill again be divided to receive 300mg/kg of curcumin orplacebo for 12 weeks , then making four experimental groupsindependent ( P , P + curcumin , PF , PF + curcumin , n = 15 animals / group ) . TheObesity is characterized by adiposity index , comorbidities :systemic blood pressure, glycemic , lipid , inflammatory and hormonal profiles ;oral glucose tolerance test will be analyzed . Statistical analysis will beperformed according to the status of the data obtained during the search.