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Involvement of TRPM8 channels in thermoregulation of Wistar rats

Grant number: 13/25503-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2015
Effective date (End): February 28, 2018
Field of knowledge:Biological Sciences - Physiology - General Physiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Maria Camila Almeida
Grantee:Robson Cristiano Lillo Vizin
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated scholarship(s):16/01836-3 - Assessment of the influence of mild chronic intermittent cold exposure on the core body temperature, cognitive function, and phosphorylated Tau and BAG2 levels in familial and sporadic mouse models of Alzheimer's Disease, BE.EP.DR


Internal body temperature (Tb), among other vital signs, is extremely important for maintaining homeostasis of living organisms, since it influences the majority, if not all, physiological and pathophysiological processes. Regulation of Tb is made by autonomic and behavioral thermoregulatory mechanisms, and influenced by ambient temperature. However, the molecular mechanisms for detecting the ambient and Tb are not well known. With the recent discovery of the temperature sensitive thermo-TRP channels (Transient Receptor Potential) it is expected a great advance in the current scenario. Previous studies from our laboratory inspired the development of this project, which aims at studying the involvement of TRPM8 channels, activated at temperatures below ~25C degrees Celsius and menthol, on the autonomic and behavioral thermoregulatory mechanisms. Animal models and acute and chronic treatments with menthol will be used. The influence the TRPM8 channels activation on Tb will be evaluated focusing on the understanding of which effector (autonomic or behavioral) mechanisms are recruited to develop the thermoregulatory response to the TRPM8 agonist. Tail, brown adipose tissue (BAT) temperature and the selection between two Ta will be tested. Additionally, we will study molecular changes in the number of expression of TRPM8 in dorsal root ganglia neurons, c-Fos expression and activity of BAT by the expression of UCP-1, and anatomical and histological changes in this tissue. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LILLO VIZIN, ROBSON CRISTIANO; CARRETTIERO, DANIEL CARNEIRO; ISHIKAWA, DEBORA T.; CRUZ-NETO, ARIOVALDO P.; ALMEIDA, MARIA CAMILA. Ruthenium red attenuates brown adipose tissue thermogenesis in rats. Journal of Thermal Biology, v. 95, . (15/23426-9, 13/25503-5, 15/02991-0)
LILLO VIZIN, ROBSON CRISTIANO; MOTZKO-SOARES, ANNA CAROLINA P.; ARMENTANO, GIOVANA MARCHINI; ISHIKAWA, DEBORA T.; CRUZ-NETO, ARIOVALDO P.; CARRETTIERO, DANIEL CARNEIRO; ALMEIDA, MARIA CAMILA. Short-term menthol treatment promotes persistent thermogenesis without induction of compensatory food consumption in Wistar rats: implications for obesity control. Journal of Applied Physiology, v. 124, n. 3, p. 672-683, . (13/25503-5, 15/02991-0, 15/23426-9)
ISHIKAWA, DEBORA T.; LILLO VIZIN, ROBSON CRISTIANO; DE SOUZA, CRISTIANE OLIVEIRA; CARRETTIERO, DANIEL CARNEIRO; ROMANOVSKY, ANDREJ A.; ALMEIDA, MARIA CAMILA. Camphor, Applied Epidermally to the Back, Causes Snout- and Chest-Grooming in Rats: A Response Mediated by Cutaneous TRP Channels. PHARMACEUTICALS, v. 12, n. 1, . (13/25503-5, 15/23426-9, 15/02991-0)
MELO, C.; VIZIN, R. C. L.; SILVA, N. U.; ISHIKAWA, D. T.; ECHEVERRY, M. B.; CARRETTIERO, D. C.; ALMEIDA, M. C.. Early maternal separation promotes alterations in the thermoregulatory profile of adult Wistar rats. Journal of Thermal Biology, v. 78, p. 151-160, . (13/25503-5, 15/23426-9, 15/02991-0)
MOTZKO-SOARES, A. C. P.; VIZIN, R. C. L.; MARTINS, T. M. S.; HUNGARO, A. R. O.; SATO, J. R.; ALMEIDA, M. C.; CARRETTIERO, D. C.. Thermoregulatory profile of neurodegeneration-induced dementia of the Alzheimer's type using intracerebroventricular streptozotocin in rats. ACTA PHYSIOLOGICA, v. 224, n. 2, . (13/25503-5, 15/02991-0, 15/23426-9)

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