Design and synthesis of hybrid mesoporous materials as "smart" system for anticancer drug delivery

• Grant number: 15/06671-0
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: September 01, 2015
• End date: August 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Osvaldo Novais de Oliveira Junior
• Grantee: Heveline Dal Magro Follmann
• Supervisor: Tewodros Asefa
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Institution abroad: Rutgers The State University of New Jersey, New Brunswick, United States
• Associated to the scholarship: 14/03511-9 - Nanostructured films of (lactated-TMC)/(CS) obtained with distinct LbL deposition methods, BP.PD

Abstract

In this research project the synthesis DLP/KCC-1 nanomaterials for delivery of anticancer drugs is intended. These nanomaterials will consist of nanosized, corrugated nanoporous silica nanoparticles with rough, "virus-like" topography, whose surfaces are functionalized with pH-responsive and DLPs. Due to their rough surface morphology, these nanoparticles are expected to enter cells effectively to deliver drugs "on demand". The resulting nanoparticles will be expected to have high drug adsorption capacity as well. They will be easily tailorable to host specific types of guest molecules with modification of their pore size, geometry and surface functional groups. The ability of the nanoparticles to: a) adsorb and release the drug to cancer cells and b) show anti-tumor activity in vitro will then be investigated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FOLLMANN, HEVELINE D. M.; OLIVEIRA, JR., OSVALDO N.; LAZARIN-BIDOIA, DANIELLE; NAKAMURA, CELSO V.; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL. Multifunctional hybrid aerogels: hyperbranched polymer-trapped mesoporous silica nanoparticles for sustained and prolonged drug release. NANOSCALE, v. 10, n. 4, p. 1704-1715, JAN 28 2018. (13/14262-7, 15/06671-0, 14/03511-9)

FOLLMANN, HEVELINE D. M.; NAVES, ALLINY F.; ARAUJO, RAFAEL A.; DUBOVOY, VIKTOR; HUANG, XIAOXI; ASEFA, TEWODROS; SILVA, RAFAEL; OLIVEIRA, JR., OSVALDO N.. Hybrid Materials and Nanocomposites as Multifunctional Biomaterials. CURRENT PHARMACEUTICAL DESIGN, v. 23, n. 26, p. 3794-3813, 2017. (13/14262-7, 15/06671-0, 14/03511-9)