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The role of kinin receptors (B1R and B2R) in the repair of skeletal muscle: new therapeutic approaches to muscle injuries

Grant number: 15/03541-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2015
Effective date (End): July 04, 2020
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:João Bosco Pesquero
Grantee:Leonardo Martins Silva
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated scholarship(s):17/26427-1 - The role of B1 and B2 receptors in fibrosis: a histomorphometric study, BE.EP.DR

Abstract

The Renin-Angiotensin (RAS) and Kalikrein-Kinin (KKS) systems play an important role in the regulation of several physiological and pathologic processes related to the control of blood pressure and also affect a large number of processes such as cell growth and proliferation, pain and inflammation, among others. The main effector substance of the RAS is angiotensin II (Ang II), and those of the KKS are bradykinin (BK) and other kinins. Kinins, as well as Ang II act through the activation of G protein coupled receptors (GPCRs): angiotensin receptors AT1 and AT2, and BK receptors B1 e B2. Both RAS and KKS systems are linked to inflammatory processes. Muscle injury is the event that occurs more often among athletes and is the main reason for the abandonment of their activities. Repair of the damaged muscle tissue is a slow process and often incomplete due to exacerbated fibrosis. During tissue repair it is necessary angiogenesis (also arteriogenesis and vasculogenesis), myogenesis and fibrogenesis simultaneously, and these processes are regulated by several growth and angiogenic factors. Our group as well as others, have studied some functions in different biological systems in the presence or absence of kinin receptors separately. However, a study demonstrating the effects caused by the presence or absence of these receptors involving the main events of skeletal muscle tissue repair, has not been performed. Similarly, a better detailing on the main cellular and molecular changes resulting from these changes is required. Therefore, this study aims to investigate the functions of B1 and B2 receptors and their role in the angiogenic, fibrogenic and myogenic tissue repair of skeletal muscle after injury events. (AU)