Porphyrins and Phthalocyanines are compounds which have been extensively studied as photosensitizers in different areas, including photodynamic therapy (PDT), production of semiconductors, gas sensors, dye-sensitized solar cells, liquid crystals, among other applications. Thus, in this research project, we propose to carry out the synthesis of new phthalocyanine-type photosensitizers starting from high conjugated phthalonitriles obtained from multicomponent reactions (MCRs) in the presence of niobium pentachloride (NbCl5). In a second part of the project, we intend to synthesize two metal tetra-beta-formylporphyrins which will be also employed in MCRs with NbCl5, to obtain high conjugated porphyrin derivatives. The metal tetra-beta-formylporphyrins will also be converted into their respective vinylporphyrins through the Wittig reaction, and then used in the Diels-Alder reactions with maleimides to yield chlorin and bacteriochlorin photosensitizers. Photophysical studies will be performed in order to evaluate the optical properties of the synthetized compounds, aiming at application in solar cells and photonic therapies. (AU)
News published in Agência FAPESP Newsletter about the scholarship:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, TAYNARA L.;
BARTOLOMEU, ALOISIO DE A.;
DE JESUS, HUGO C. R.;
DE OLIVEIRA, KLEBER T.;
FERNANDES, JOAO B.;
VIEIRA, PAULO C.
New Synthetic Quinolines as Cathepsin K Inhibitors.
Journal of the Brazilian Chemical Society,
Web of Science Citations: 0.