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Programmed cell death photoinduced mechanisms and different gene expression profiles

Grant number: 15/07768-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2015
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Biophysics
Principal Investigator:Mauricio da Silva Baptista
Grantee:Felipe Gustavo Ravagnani
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:12/50680-5 - Photosensitization in life sciences, AP.TEM

Abstract

Photodynamic therapy (PDT - Photodynamic therapy) is a treatment against several human diseases whose basic principle is the use of a photosensitive molecule, which is internalized by the cell and excited with visible light (600-800nm), generating several reactive species and inducing cell death in the target tissues. The main objective of the thematic research grant is to identify mechanisms to induce programed cell death, using light. In previous studies, we characterized ways to induce, with similar photosensitizers, distinct mechanisms of programmed cell death. This induction was shown to be dependent mainly on the cellular localization of the photosensitizer. Although the lab focus has always been in eukaryotic cells, we intend, in the coming years, to also apply these concepts in prokaryotes organisms. In this project we will compare qualita tively and quantitatively the gene expression induced by the photosensitivity reactions depending on the cellular localization of the photosensitizer and on the type of programmed cell death. Furthermore, we also aim to expand these studies to prokaryotic organisms.

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