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Antibiofilm effect of a glass ionomer cement containing natural products

Grant number: 15/08871-6
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): September 01, 2015
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Pedro Luiz Rosalen
Grantee:Aline Rogéria Freire de Castilho
Supervisor abroad: Simone Duarte
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Local de pesquisa : New York University, United States  
Associated to the scholarship:14/01723-9 - Characterization of a glass ionomer cement containing natural products: in vitro and in vivo studies, BP.PD


Considering that natural compounds are promising agents in the control and treatment of dental caries, it seems reasonable that their association with dental materials may improve the anticaries effect of the material. Specifically, the incorporation of flavonoids, terpenoid and benzophenone into glass ionomer cement (GIC) demonstrated growth inhibition of cariogenic bacteria strains, according to preliminary results of our research group. Whilst the antimicrobial activity can be effective against cariogenic pathogens, the acidogenicity and composition of Streptococcus mutans biofilm on glass ionomer cements (GICs) and the anti-S. mutans biofilm activity is still unknown and must be considered. Considering our preliminary data for GIC characterization were promising, the aim of this study is to elucidate the antibiofilm effect of a glass ionomer cement containing natural products, as part of original postdoctoral project (FAPESP 2014/ 01723-9). Thus, we have established a partnership with the New York University College of Dentistry (New York, NY, USA) to perform advanced methodologies for biofilm analysis in a worldwide reference center. Briefly, we will carry out the follow methodologies: biofilms' inhibition and structural organization analyzed by biochemical assays (biomass, polysaccharide and proteins), laser scanning confocal fluorescence imaging and scanning microscopy via the variable pressure scanning electron microscope (assay not available in Brazil).

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