| Grant number: | 15/08871-6 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | September 01, 2015 |
| End date: | August 31, 2016 |
| Field of knowledge: | Health Sciences - Dentistry - Social and Preventive Dentistry |
| Principal Investigator: | Pedro Luiz Rosalen |
| Grantee: | Aline Rogéria Freire de Castilho |
| Supervisor: | Simone Duarte |
| Host Institution: | Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil |
| Institution abroad: | New York University, United States |
| Associated to the scholarship: | 14/01723-9 - Characterization of a glass ionomer cement containing natural products: in vitro and in vivo studies, BP.PD |
Abstract Considering that natural compounds are promising agents in the control and treatment of dental caries, it seems reasonable that their association with dental materials may improve the anticaries effect of the material. Specifically, the incorporation of flavonoids, terpenoid and benzophenone into glass ionomer cement (GIC) demonstrated growth inhibition of cariogenic bacteria strains, according to preliminary results of our research group. Whilst the antimicrobial activity can be effective against cariogenic pathogens, the acidogenicity and composition of Streptococcus mutans biofilm on glass ionomer cements (GICs) and the anti-S. mutans biofilm activity is still unknown and must be considered. Considering our preliminary data for GIC characterization were promising, the aim of this study is to elucidate the antibiofilm effect of a glass ionomer cement containing natural products, as part of original postdoctoral project (FAPESP 2014/ 01723-9). Thus, we have established a partnership with the New York University College of Dentistry (New York, NY, USA) to perform advanced methodologies for biofilm analysis in a worldwide reference center. Briefly, we will carry out the follow methodologies: biofilms' inhibition and structural organization analyzed by biochemical assays (biomass, polysaccharide and proteins), laser scanning confocal fluorescence imaging and scanning microscopy via the variable pressure scanning electron microscope (assay not available in Brazil). | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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