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Comparative analyses of induced pluripotent stem cell-derived neurons from patients with Gaucher disease and Parkinson

Grant number: 14/24587-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2015
Effective date (End): July 31, 2019
Field of knowledge:Biological Sciences - Genetics
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Lygia da Veiga Pereira
Grantee:Fabiano Tófoli de Araújo
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/08135-2 - CTC - Center for Cell-Based Therapy, AP.CEPID

Abstract

Recent works have show association of the Gaucher Disease (GD) with Parkinson's Disease (PD), where GBA mutation carriers present a higher risk of to present Parkinsonism. However, the mechanism underlying this associations is still unknown. Induced pluripotent stem cells (iPSC) are a valuable experimental system in which to studying neurodegenerative conditions with more complex genetic predisposition, as well as metabolic diseases known to have familial predispositions but for which the genetic contribution remains unexplained. Our goal is to develop iPSC from patients with PD, carriers and non-carriers of mutations in the GBA gene, in order to study their neurogenesis in vitro. (AU)