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Synaptic plasticity in a stochastic model of neural networks

Grant number: 15/10785-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): September 01, 2015
Effective date (End): April 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Probability and Statistics
Principal Investigator:Jefferson Antonio Galves
Grantee:Guillem Via Rodriguez
Host Institution: Instituto de Matemática e Estatística (IME). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07699-0 - Research, Innovation and Dissemination Center for Neuromathematics - NeuroMat, AP.CEPID


In Galves and Loecherbach (2013), a new stochastic model for neural networks was introduced. It consists of a system comprising a countable set of interacting stochastic chains with memory of variable length. While simple enough to allow for a mathematical treatment, this model is rich enough to describe realistically neurobiological phenomena. However, at this point it presents the clear limitation of not accounting for synaptic plasticity. In mathematical terms, this means that the synaptic weights remain fixed instead of evolving as a result of neural activity, as is been observed experimentally. Extending the model in order to include these phenomena, and studying the resulting behaviour of the system, are the main aims of the present project.The neurobiological framework that embeds and at the same time motivates the project comes from one of the main open questions in neuroscience, i.e. how do neurons transmit information to each other. Synaptic plasticity, the capacity of synapses (the links between neurons) to change as a result of neural activity, seems to have a prominent role for this. This is why this plasticity will be considered, in particular in terms of spike-timing-dependent-plasticity (STDP), where the synaptic changes are determined by the precise times of neural spikes.Our project aims at tackling the aforementioned biological problem by adding the proposed extensions to the model introduced in Galves and Loecherbach (2013). This purpose will be carried out in close connection to available experimental results and the mathematical conceptual framework employed by the NeuroMat team.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PECHERSKY, EUGENE; VIA, GUILLEM; YAMBARTSEV, ANATOLY. Stochastic Ising model with plastic interactions. Statistics & Probability Letters, v. 123, p. 100-106, . (15/10785-0, 13/07699-0, 15/03452-5)

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