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Analysis of HPV11 variants in recurrent respiratory papillomatosis

Grant number: 15/06628-7
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Marilia de Freitas Calmon
Grantee:Marina Carrara Dias
Home Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

The recurrent respiratory papillomatosis (RRP) is characterized by the formation of papillomas in the respiratory tract of children and adults. Papillomas found in the larynx are benign, and can spread throughout the respiratory tract and obstruct the airway, causing death. The clinical course of the disease is variable and can occur only once or in different times. This disease is the result of infection with human papillomavirus (HPV), which have the ability to infect squamous epithelium, both skin and oral and genital mucosa. HPV can be divided into two groups according to their oncogenic potential, high-risk or low-risk, the latter group is responsible for the RRP and mainly represented by genotypes 6 and 11. HPV replication is controlled by the long control region (LCR), which activates or suppress activity of the gene promoter regulating the transcription, in particular the E6 and E7 genes. The changes in the region of virus variants may differ within one HPV type. Because the changes in LCR influence the binding of virus transcription factors, the detection of variations observed through this region is important to identify and correlate differences in clinical and pathological features that can be linked to the nucleotide variation. So, the aims of this study are to detect HPV11 variants present in the samples of RRP and correlate with disease severity, according to the clinicopathological parameters of the samples and identify changes in LCR that may influence the transcriptional activity of viruses and modulate the clinical course of the disease. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS, MARINA CARRARA; STUQUI, BRUNA; SCARIN PROVAZZI, PAOLA JOCELAN; BITTAR, CINTIA; CANDIDO, NATALIA MARIA; ADUM DE MATOS, RENATA PRANDINI; BADIAL, RODOLFO MIGLIOLI; DO BONFIM, CAROLINE MEASSO; DOS SANTOS MELLI, PATRICIA PEREIRA; QUINTANA, SILVANA MARIA; CORDEIRO, JOSE ANTONIO; RAHAL, PAULA; CALMON, MARILIA DE FREITAS. Analysis of Nucleotide Alterations in the E6 Genomic Region of Human Papillomavirus Types 6 and 11 in Condyloma Acuminatum Samples from Brazil. ADVANCES IN VIROLOGY, 2019. Web of Science Citations: 0.

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