Seroprevalence of antibodies of Cytomegalovirus among pregnant Women

• Grant number: 15/02245-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2015
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Celso Francisco Hernandes Granato
• Grantee: Flávia de Oliveira Naddeo
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Cytomegalovirus (CMV) is a DNA, double stranded virus. After the primary infection the virus remains latent in the body but can reactivate in cases of immunosuppression, such as pregnancy, chemotherapy and AIDS. Currently, CMV is the leading cause of congenital infection in developed countries, causing significant injuries to the fetus, like deafness and neurological impairment. The virus is widely distributed among human populations and its transmission is related to socioeconomical and hygienic conditions, varying among developed and developing countries. The vertical transmission is rather rare in "non - primary" infections, but in primary infections the transmission rate can be as high as 40%. In Brazil information concerning CMV seroprevalence is scarce, especially during pregnancy. The present work aims to evaluate the prevalence of past or current infections in pregnant women in the metropolitan area of Sao Paulo - Brazil, referred to a major clinical laboratory for pre-natal testing, independent of clinical suspicion of the disease.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FLÁVIA NADDEO; ANA MARIA PASSOS-CASTILHO; CELSO GRANATO. Infecção pelo citomegalovírus na gestação. Jornal Brasileiro de Patologia e Medicina Laboratorial, v. 51, n. 5, p. 310-314, 2015-10-00. (15/02245-6, 13/03701-0)