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Using of polyelectrolyte complex chitosan-pectin in carrier systems for bioactive compounds

Grant number: 15/07872-9
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2015
Effective date (End): July 31, 2019
Field of knowledge:Agronomical Sciences - Food Science and Technology - Food Engineering
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Rosemary Aparecida de Carvalho
Grantee:Vinícius Borges Vieira Maciel
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated scholarship(s):16/18142-4 - Biopolymer-based nano- and micro-particles loaded with a natural plant (Pereskia aculeata Miller) extract for delivery of iron., BE.EP.PD


Polysaccharides that present opposite charges such as chitosan and pectin when in aqueous solution can form a polyelectrolyte complex (PEC) with very strong intermolecular interaction and highly ordered orientation of the rigid-chain polymers. The main of this work will be developing carrier systems of bioactive compound with large amounts of iron (ora-pro-nobis, Pereskia aculeata Miller) using nanocomplexes (NCXs) from ionic and electrostatic interaction that exist between two natural and biodegradable polymers: chitosan and pectin. Iron is essential for most living organisms being responsible different functions such as oxygen and ATP transport on cells. Its deficiency is prejudicial for organism can lead iron deficiency anemia. Chitosan is a cationic polysaccharide composed by N-glucosamine and N-acetil glucosamine that present different degree of acetylation. Pectin is a linear anionic polysaccharide composed mainly by D-galacturonic acid with one part of carboxyl group methoxylated. NCXs will be prepared like micro and nanoparticles to evaluate the complexation of bioactive compound ora-pro-nobis and its iron release mechanisms in in vitro systems. The NCXs will be obtained from homogenization of chitosan (5.0 mg/mL) and pectin (5.0 mg/mL) solutions at different pHs (2.7, 4.0, 5.0 and 5.5), charge ratios (n+/n-, 0.10, 0.25, 0.50, 0.75, 1.00, 1.33, 2.00, 4.00 e 5.00), total charge (n+ + n-, 1.0 x 10-6, 2.0 x 10-6 e 3.0 x 10-6) and molarity of NaCl solutions (50, 100 ou 200 mM) used to solubilized the polysaccharides. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACIEL, VINICIUS B. V.; YOSHIDA, CRISTIANA M. P.; GOYCOOLEA, FRANCISCO M.. Agronomic Cultivation, Chemical Composition, Functional Activities and Applications of Pereskia Species - A Mini Review. Current Medicinal Chemistry, v. 26, n. 24, p. 4573-4584, . (15/07872-9)
MACIEL, VINICIUS B. V.; REMEDIO, LEANDRO N.; YOSHIDA, CRISTIANA M. P.; CARVALHO, ROSEMARY A.. Carboxymethyl cellulose-based orally disintegrating films enriched with natural plant extract for oral iron delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 66, . (15/07872-9)
MACIEL, VINICIUS B. V.; YOSHIDA, CRISTIANA M. P.; BOESCH, CHRISTINE; GOYCOOLEA, FRANCISCO M.; CARVALHO, ROSEMARY A.. Iron-rich chitosan-pectin colloidal microparticles laden with ora-pro-nobis (Pereskia aculeata Miller) extract. FOOD HYDROCOLLOIDS, v. 98, . (16/18142-4, 15/07872-9)
VINICIUS BORGES VIEIRA MACIEL; RENATA QUEIROZ BEZERRA; EDUARDO GALVÃO LEITE DAS CHAGAS; CRISTIANA MARIA PEDROSO YOSHIDA; ROSEMARY APARECIDA DE CARVALHO. Ora-pro-nobis (Pereskia aculeata Miller): uma fonte potencial de ferro e compostos fitoquímicos. Brazilian Journal of Food Technology, v. 24, . (16/03957-2, 15/07872-9)

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