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Immunotherapy of experimental asthma by agonists of toll-like receptors

Grant number: 15/16728-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2015
Effective date (End): January 31, 2018
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Momtchilo Russo
Grantee:Fernanda Peixoto Barbosa Nunes
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/24694-1 - Immunotherapy of experimental asthma by agonists of toll-like receptors, infection or tolerance, AP.TEM

Abstract

The prevalence and severity of allergy, including asthma, are on the rise worldwide. At present, asthma is considered a lung chronic inflammatory disease and its classic form is associated with uncontrolled T helper (Th)2 cells activity. Murine models have been developed to investigate mechanisms of asthma, and ovalbumin (OVA) is the most commonly used allergen. However, this protein is a food and not an airborne allergen. Experimental models of lung allergic disease were then adapted to airborne allergens such as those derived from house dust mite. Blomia tropicalis (Bt) is the most prevalent mite in Brazil. In our lab, we recently developed an experimental model of allergic asthma using Bt extract. In previous studies using OVA as allergen, we have shown that immune activation by agonists of Toll-like receptors (TLR)s is a potent mechanism to attenuate allergic reactions. Based on these studies and on recent data, we postulated that TLR agonists can attenuate allergic responses by direct or indirect inhibition of Th2 activity. The present project aims to delineate prophylactic but mainly therapeutic applications of TLR agonists to inhibit asthma using OVA or Bt extract as allergens.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALBERCA-CUSTODIO, RICARDO WESLEY; FAUSTINO, LUCAS D.; GOMES, ELIANE; NUNES, FERNANDA PEIXOTO BARBOSA; DE SIQUEIRA, MIRIAN KRYSTEL; LABRADA, ALEXIS; ALMEIDA, RAFAEL RIBEIRO; CAMARA, NIELS OLSEN SARAIVA; DA FONSECA, DENISE MORAIS; RUSSO, MOMTCHILO. Allergen-Specific Immunotherapy With Liposome Containing CpG-ODN in Murine Model of Asthma Relies on MyD88 Signaling in Dendritic Cells. FRONTIERS IN IMMUNOLOGY, v. 11, APR 23 2020. Web of Science Citations: 0.
ALBERCA CUSTODIO, RICARDO W.; MIROTTI, LUCIANA; GOMES, ELIANE; NUNES, FERNANDA P. B.; VIEIRA, RAQUEL S.; GRACA, LUIS; ALMEIDA, RAFAEL R.; CAMARA, NIELS O. S.; RUSSO, MOMTCHILO. Dendritic Cells Expressing MyD88 Molecule Are Necessary and Sufficient for CpG-Mediated Inhibition of IgE Production In Vivo. CELLS, v. 8, n. 10 OCT 2019. Web of Science Citations: 0.
NUNES, FERNANDA P. B.; ALBERCA-CUSTODIO, RICARDO WESLEY; GOMES, ELIANE; FONSECA, DENISE M.; YOKOYAMA, NICOLE H.; LABRADA, ALEXIS; RUSSO, MOMTCHILO. TLR9 agonist adsorbed to alum adjuvant prevents asthma-like responses induced by Blomia tropicalis mite extract. Journal of Leukocyte Biology, v. 106, n. 3, SI JULY 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.

Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180703390 - Universidade de São Paulo (USP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - October 2018, 02