Hybrid materials based on silica and polyetheramines as a dual-drug-delivery vehicle

• Grant number: 15/02802-2
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): September 01, 2015
• Effective date (End): February 28, 2017
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Eduardo Ferreira Molina
• Grantee: Beatriz Bernardes Caravieri
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 13/20455-2 - Nanostructured organic-inorganic hybrids for controlled lignans release with pharmacological potential, AP.JP

Abstract

One of the dominant strategies to obtain a controlled drug release system are organic-inorganic hybrid materials which combine different properties of the two phases into a single structure.These systems have the ability to incorporate large amounts of drugs, efficiently, reducing the occurrence of side effects during treatment, causing the release from them is very important for both academic and industrial areas.The main objective of this work is to evaluate the incorporation of two model drugs, naproxen and 5-fluorouracil (5-FU) in hybrid matrices based on siloxane-polyether (polyoxypropylene - PPO) for further simultaneous release of drugs, under the influence of pH. These matrices are prepared by sol-gel process.Structural changes and the release profile of the incorporated drugs simultaneously, will be assessed by different techniques such as XRD, FTIR, SAXS, DSC and UV-vis. The first drug belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs) and the second, to the class of antineoplastic. Because they have different chemical structures, their coordination sites are different.Thus, taking into account the pH as external stimulus, each drug will present a specific controlled-release profile from the matrix. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARAVIERI, BEATRIZ B.; DE JESUS, NATANA A. M.; DE OLIVEIRA, LILIAN K.; ARAUJO, MARINA D.; ANDRADE, GABRIELE P.; MOLINA, EDUARDO F.. Ureasil Organic-Inorganic Hybrid as a Potential Carrier for Combined Delivery of Anti-Inflammatory and Anticancer Drugs. ACS APPLIED BIO MATERIALS, v. 2, n. 5, p. 9-pg., 2019-05-20. (15/02802-2, 13/20455-2)