Immunomodulation by human umbilical cord wall-derived mesenchymal stem cells during differentiation, senescence, and when treated with IL-11

• Grant number: 14/17292-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2015
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Anna Carla Renata Krepel Goldberg
• Grantee: Fernanda Vieira Paladino
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

This study aims to improve the comprehension of the mechanisms involved in the modulation of the immune response carried out by mesenchymal stem cells in an inflammatory environment. These mechanisms have been well studied in mesenchymal cells derived from bone marrow but not from umbilical cord wall, an interesting alternative source for the purpose of cell therapy. Still largely unknown, the variability of the basal production and secretion profiles of immunosuppressive cytokines, as well as the changes when cells are expanded or when replicative senescence is reached will be evaluated. The analysis of this last item is essential considering that large scale expansion is necessary to obtain enough cells for cell therapy protocols. We aim also to focus on IL-11, a cytokine known for its classical function in hematopoiesis, osteotrophic induction, and placental development but with unknown function in mesenchymal cells. We will compare the results from cord wall-derived cells with mesenchymal cells obtained from young and aged bone marrow from healthy individuals.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PALADINO, Fernanda Vieira. Immunomodulatory potential of human mesenchymal stem cells from Wharton\'s jelly progressing to replicative senescence. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.