Poly (acrylic acid) / PEO-PPO-PEO hydrogels for nitric oxide delivery for topical injuries

• Grant number: 15/17515-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2015
• End date: October 31, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Marcelo Ganzarolli de Oliveira
• Grantee: Lucas Militão
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Nitric oxide (NO) has a major role in several physiological processes with highlighted wound healing action associated with the stimulation of cell proliferation, vasodilation and angiogenesis. Due to these actions, the topical application of NO has been shown to be effective in the treatment of several types of skin lesions and in particular in the treatment of chronic lesions. The main objective of this project is the development of double network hydrogel membranes capable of absorbing exudate and releasing NO topically in adequate amounts and prolonged times. The hydrogels will be synthesized from the polymerization of acrylic acid in the presence of the triblock copolymer of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO). These hydrogels will be loaded with S-nitrosoglutathione (GSNO) as a NO donor agent. The kinetics of real-time NO release will be characterized by chemiluminescence. The membranes will also be characterized regarding their morphological, mechanical and thermal properties. The wound healing actions of the membranes will be evaluated in vivo in an animal model in collaboration with Prof. Andrea Monte-Alto Coast form UERJ, RJ. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CHAMPEAU, MATHILDE; POVOA, VALERIA; MILITAO, LUCAS; CABRINI, FLAVIA M.; PICHETH, GUILHERME F.; MENEAU, FLORIAN; JARA, CARLOS P.; DE ARAUJO, ELIANA P.; DE OLIVEIRA, MARCELO G.. Supramolecular poly(acrylic acid)/F127 hydrogel with hydration-controlled nitric oxide release for enhancing wound healing. Acta Biomaterialia, v. 74, p. 312-325, JUL 1 2018. (16/02414-5, 17/19253-7, 14/24955-2, 15/17515-9, 13/07607-8)