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Computer simulation study of the effects of amyotrophic lateral sclerosis on the dynamical behavior of mathematical models of lower motor neurons

Grant number: 15/14917-9
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2015
Effective date (End): August 31, 2017
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Leonardo Abdala Elias
Grantee:Débora Elisa da Costa Matoso
Home Institution: Faculdade de Engenharia Elétrica e de Computação (FEEC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Mathematical modeling and computer simulations have been widely used in the neural sciences to provide theoretical/conceptual foundations on the mechanisms involved in the functioning of the nervous system. Specifically, mathematical models of alpha motor neurons (MNs) have supported investigations on the dynamical behavior of individual cells under different experimental conditions. Also, a population of MN models has been used to represent motor nuclei so as to study the muscle force control. Recent computational neuroscience studies proposed complex mathematical models of MNs with morphological, biophysical, and electrophysiological features of animal models of amyotrophic lateral sclerosis (ALS). These MN models have aided the understanding of different mechanisms operating at the onset and during the progression of this neurodegenerative disease, which affects motor neurons. This research project aimed at developing new biologically plausible and computationally efficient MN models that encompass the main geometrical, electrotonic and electrophysiological characteristics of animal models of ALS. These new models would advance the understanding of underlying mechanisms of ALS from a single-cell standpoint. Additionally, due to their computational efficiency these models may be used in future multi-scale models of the neuromuscular system intended to investigate the control/generation of muscle force in ALS patients.

Articles published in Agência FAPESP about the scholarship:
Model aids understanding of how amyotrophic lateral sclerosis affects neurons 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.
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