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Study of the role of the Macrophage Migration Inhibitory Factor in the modulation of the tumor inflammatory infiltrate and progression of oral squamous cell carcinoma

Grant number: 15/15170-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marcos Brasilino de Carvalho
Grantee:Mariana Barbosa de Souza Rizzo
Supervisor abroad: Robert A. Mitchell
Home Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Local de pesquisa : University of Louisville (UofL), United States  
Associated to the scholarship:15/02584-5 - The role of the Macrophage Migration Inhibitory Factor in the modulation of the tumor inflammatory infiltrate and progression of oral squamous cell carcinoma, BP.DR

Abstract

INTRODUCTION. Inflammation participates in the different stages of carcinogenesis and tumor progression in the most of the neoplasms. The cancer-associated inflammation, including tumor-associated macrophages, plays different mechanisms depending on the type and frequency of received stimuli, and according of this can display pro or anti-tumor functions. MIF protein acts in the modulation of the tumor immune response and a range of investigations have shown that it can induce the polarization of macrophages located in the tumor stroma to an immunosuppressive and protumoral M2 phenotype. OBJECTIVES. The present study aims assess in vitro the role of MIF protein on the modulation of tumor-associated macrophages and the impact of it on oral squamous cell carcinoma behavior. METHODS. Macrophages from tumor tissue, as well as from healthy subject´s peripheral blood will be obtained and treated in vitro with conditioned media from MIF knockout and wild type SCC15 and SCC25 oral squamous cell carcinoma cell lines. Then the macrophages will be evaluated based on the M1 and M2 phenotype. Functional experiments will be performed to verify the role of the different tumor-associated macrophage´s phenotypes in SCC´s migration, invasion and proliferation.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA RIZZO, M. BARBOSA; BRASILINO DE CARVALHO, M.; KIM, E. J.; RENDON, B. E.; NOE, J. T.; WISE, A. DARLENE; MITCHELL, R. A. Oral squamous carcinoma cells promote macrophage polarization in an MIF-dependent manner. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, v. 111, n. 11, p. 769-778, NOV 2018. Web of Science Citations: 0.

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