Advanced search
Start date
Betweenand

Prevalence of auditory and vestibular symptoms in sickle cell disease

Grant number: 15/14706-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2015
Effective date (End): October 31, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Maria Stella Figueiredo
Grantee:Murilo Henrique Dela Páscoa Toranzo
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

BACKGROUND AND OBJECTIVES: Sickle Cell Disease (SCD) is a generic term used to determine a group of genetic alterations characterized by hemoglobin S (Hb S) predominance. Sickle cell anaemia (SCA), the most common and severe SCD, is an autosomal recessive, inherited disorder of haemoglobin structure caused by a point mutation in the Beta²-globin chain of haemoglobin. Low blood oxygenation promotes the polymerisation of haemoglobin, which distorts red blood cells into a sickle shape and reduces their elasticity. Consequently, these rigid and abnormally shaped blood cells are unable to deform as they pass through narrow capillaries, leading to vessel occlusion and ischaemia. Recent discoveries allowed SCD patients benefit from early diagnosis and better options of treatment. With longer longevity, the incidence of new complications of SCD became apparent and previously milder complications became more severe and more common. The otological complications of SCD are examples of these changes that have become more common than before. However, there is a wide variety of data regarding the incidence, prevalence and management of these complications. Therefore, it is necessary a study covering the analysis of the patient stricken by this disorder and its prevalence among brazilian patients with SCD. Besides, as the labyrinthine artery irrigates both the cochlea and the vestibule, it is also necessary to search for any symptom that is typical of its involvement (tinnitus and dizziness).METHODS: This study has an analytical, transversal, clinical research plan. Will be included 50 SCD patients and 50 healthy individuals in the control group matched for age and sex.Analysed aspects:1.Hemoglobin type (SS, Sbeta ou SC)2.Hemogram (hemoglobin level, hematocrit, DHL)3.Hematologic questionnaire:a.Number of vaso-occlusive crisisb.Acute thoracic syndromec.Osteonecrosis4.Audiological questionnaire:a.Hearing lossb.Dizzinessc.Tinnitus5.Audiometry6.Impedanciometry7.Otoacoustic emissionsThe size of the sample was calculated using POCOCK (1983) formula.