Triboelectric effect as a novel tool for the development and application of point-of-care testing devices

• Grant number: 15/13810-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2015
• End date: October 31, 2017
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Lauro Tatsuo Kubota
• Grantee: Everson Thiago Santos Gerôncio da Silva
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/22127-2 - Development of novel materials strategic for integrated analytical devices, AP.TEM

Abstract

This research project is aimed at the development of point-of-care (POC) testing devices for the analysis of samples with biological interest, using the triboelectric effect as a method for the assembly and operation of the device. In this work, we employed a new concept of digital microfluidics based on triboelectrification of a substrate with a controlled modification of the surface charge to promote movement and handling of liquid samples in a simple and practical way. Some flexible low cost platforms, such as teflon film, polyester or modified paper (chemically or physically), will be investigated for the manufacture of the device, taking into consideration also their triboelectric properties. At first, it will be carried out a study of static charges on the surface of the substrate employed due to friction or simple contact with this other material of triboelectric series. The possibility of obtaining and handling patterns of charge on the device surface to promote the targeting of small sample volumes will be also held. Subsequently the device will be coupled with an analytic detection system, such as the electrochemical method, to obtain an integrated microfluidic platform for POC diagnostic. Thus, microelectrodes will be made employing a low-cost deposition method recently developed in our group. Finally, the detection of glucose using an enzymatic assay will be carried out as a proof of concept for the device characterization.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, EVERSON T. S. G.; ALVES, THAIS M. R.; KUBOTA, LAURO T.. Direct Toner Printing: A Versatile Technology for Easy Fabrication of Flexible Miniaturized Electrodes. Electroanalysis, v. 30, n. 2, p. 345-352, FEB 2018. (15/13810-6)

DA SILVA, EVERSON T. S. G.; SOUTO, DENIO E. P.; BARRAGAN, JOSE T. C.; GIAROLA, JULIANA DE F.; DE MORAES, ANA C. M.; KUBOTA, LAURO T.. Electrochemical Biosensors in Point-of-Care Devices: Recent Advances and Future Trends. CHEMELECTROCHEM, v. 4, n. 4, p. 778-794, APR 2017. (13/22127-2, 16/04739-9, 15/13810-6)

BARRAGAN, JOSE T. C.; DA SILVA, EVERSON T. S. G.; DE MORAES, ANA C. M.; KUBOTA, LAURO T.. A novel approach for electroanalytical determinations employing discharge of pseudocapacitor by electroactive species. Analytica Chimica Acta, v. 1006, p. 1-9, MAY 2 2018. (14/50867-3, 13/22127-2, 16/04739-9, 15/13810-6)

BARRAGAN, JOSE T. C.; KOGIKOSKI, JR., SERGIO; DA SILVA, EVERSON T. S. G.; KUBOTA, LAURO T.. Insight into the Electro-Oxidation Mechanism of Glucose and Other Carbohydrates by CuO-Based Electrodes. Analytical Chemistry, v. 90, n. 5, p. 3357-3365, MAR 6 2018. (16/14507-8, 14/50867-3, 13/22127-2, 15/13810-6)

BARRAGAN, JOSE T. C.; DA SILVA, EVERSON T. S. G.; DE MORAES, ANA C. M.; KUBOTA, LAURO T.. A novel approach for electroanalytical determinations employing discharge of pseudocapacitor by electroactive species (vol 1006, pg 1, 2018). Analytica Chimica Acta, v. 1031, p. 1-pg., 2018-11-15. (13/22127-2, 16/04739-9, 15/13810-6, 14/50867-3)