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Radiological and scanning electron microscopy aspect of the interface between the composite, made of chitosan and polymethylmethacrylate and the bone failure of the rabbit tibia

Grant number: 15/17496-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2015
Effective date (End): October 31, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal researcher:Silvio Henrique de Freitas
Grantee:Gabriela de Souza Kuhl
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil


The orthopedic diseases with bone loss are the challenge in both veterinary and human medicine. Therefore, the orthopedist commonly deal with irreducible comminuted fractures of long bones, bone tumors or non-unions, which require repairers surgical procedures, through the segment replacement or bone defect filling with natural or synthetic biomaterials. The aim of this research is to analyze and compare the reactions at the interface between the composite, made of chitosan and polymethylmethacrylate, and the bone defect (receptor site) of the rabbits tibia through radiological and microscopic techniques by scanning electron microscopy, in different times. In this study will be used 12 adult New Zealand rabbits, divided into four experimental groups (E1, n = 3; E2, n = 3; E3, n = 3 and E4, n = 3), which will have the right tibial bone defects filled with composite, and evaluated in the immediate postoperative, 30, 60, 90 and 120 days. It is expected as a result the incorporation and osteointegration of the composite in the bone failure of the rabbits tibia.

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