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The role of AMH signaling on sex differentiation and gametogenesis of teleost fish

Grant number: 15/15631-1
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): February 08, 2016
Effective date (End): February 07, 2017
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Rafael Henrique Nóbrega
Grantee:Marcos Antônio de Oliveira
Supervisor: Manfred Schartl
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: Universität Würzburg, Germany  
Associated to the scholarship:14/25313-4 - The role of AMH on sex differentiation and gametogenesis of teleost fish, BP.DR


Amh signaling is an important effector in the decision whether the bipotencial gonad anlage will become a testis or ovary. Studies with Medaka hotei, where Amh type II receptor (Amhr2) is mutated showed an overproliferation of germ cells and a male-to-female sex reversal. Our hypothesis is that Amh regulates germ cell number, which may influence the sex differentiation decision in Medaka. Moreover, Amh might have a role in adult gametogenesis. Therefore, we aimed to evaluate Amh signaling during sex differentiation and gametogenesis. For that transgenic lines overexpressing amhr2 or lacking amh/amhr2 will be generated in Medaka. Genetic screening for Y chromosome contrasted with gonad histology will be performed to evaluate sex reversal. Moreover, number of germ cells, proliferation and steroid release will be conducted in each transgenic line to unravel the role of Amh signaling in Medaka gametogenesis. All these data will provide evidences to better understand the role of Amh as an important effector in the control of germ cell number, which might influences the sex differentiation decision and gametogenesis in Medaka. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DU, KANG; WUERTZ, SVEN; ADOLFI, MATEUS; KNEITZ, SUSANNE; STOECK, MATTHIAS; OLIVEIRA, MARCOS; NOBREGA, RAFAEL; ORMANNS, JENNY; KLOAS, WERNER; FERON, ROMAIN; et al. The genome of the arapaima (Arapaima gigas) provides insights into gigantism, fast growth and chromosomal sex determination. SCIENTIFIC REPORTS, v. 9, . (14/25313-4, 14/50602-0, 15/15631-1, 14/07620-7)

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