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Adsorption of Proteins on Charged Confining Surfaces

Grant number: 15/15297-4
Support Opportunities:Scholarships abroad - Research
Effective date (Start): February 01, 2016
Effective date (End): July 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Sidney Jurado de Carvalho
Grantee:Sidney Jurado de Carvalho
Host Investigator: Andrey G. Cherstvy
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
Research place: University of Potsdam, Germany  


The adsorption of proteins on charged confining surfaces has attracted great interest because of its great potential for applications. Nevertheless, the dominant interactions that stabilize the adsorption and the conditions under which the adsorbed protein maintains its properties and biological function are not yet fully understood. Particularly, the effect of the surface electric potential on the degree of protonation of the residues (charge regulation) and its contribution to adsorption are not normally considered in experimental results interpretation. It is proposed in this project a computer simulation study of confined proteins in charged surfaces of different geometries. Adopting a simplified model in which the intramolecular potentials are based on the native structure and the electrostatic interactions are considered according to the Debye-Huckel theory, it is intended to provide an overview of how the different contributions of electrostatic interaction (charge-charge, charge-dipole and charge regulation) affect the adsorption and the maintaining of the native structure.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CARVALHO, SIDNEY J.; METZLER, RALF; CHERSTVY, ANDREY G.. Critical adsorption of polyelectrolytes onto planar and convex highly charged surfaces: the nonlinear Poisson-Boltzmann approach. NEW JOURNAL OF PHYSICS, v. 18, . (15/15297-4)

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