Influence of peptidyl deiminase 4 and anti citrullinated antibody on the length of stay and mortality in patients after acute myocardial infarction

• Grant number: 15/07777-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2015
• Effective date (End): October 31, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcos Ferreira Minicucci
• Grantee: Evelyn Aparecida da Silva
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Cardiovascular diseases are considered the major cause of death worldwide. Among them, due to the high rates of mortality, we can highlight the acute myocardial infarction (MI). After MI occur complex alterations on ventricular architecture and increase in inflammatory cytokines in the infarcted zone. These inflammatory factors are related to a worse prognosis after MI. Recently, Recently, some studies showed the association between inflammatory process and the process known as citrullination. Protein citrullination is the posttranslational modification of peptidylarginine into peptidylcitrulline catalized by peptidylarginine deiminase enzymes (PAD). The PAD4-mediated citrullination of histones may participate in altered gene regulation and in neutrophil extracellular traps (NETs) formation. NETs are an important innate immune mechanism to fight pathogenic bacteria and fungi. In addition, citrullination can stimulate the immunological system to produce anti-citrullinated antibodies (anti-CCP). Thus, the objective of this study is to evaluate the influence of serum PAD4 concentration and the presence of anti-CCP on the length of stay and mortality in patients after acute myocardial infarction.