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Immunohistochemical characterization of galectin-3 as a prognostic tool in canine oral melanomas

Grant number: 15/11959-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Ricardo de Francisco Strefezzi
Grantee:Thiago Henrique Moroni Vargas
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Melanomas originate from melanocytes or melanoblasts and are locally aggressive, with high metastatic potential and represent 4% of all malignancies in dogs. Melanomas may affect the oral cavity, skin and eyes. Melanomas in domestic animals have poor prognosis, because it is usually diagnosed at an advanced stage, in which the excision is uneffective. Galectin-3 is a protein found mainly in the cytoplasm and has several biological functions associated with cell proliferation, adhesion, migration, invasion, angiogenesis and apoptosis, depending on the location. Despite being considered a prognostic marker for certain cancer types, further studies are needed to elucidate its relationship with neoplastic biology and prognosis. This study aims to characterize the immunohistochemical expression of galectin-3 in malignant canine oral melanoma, comparing the results with other already established prognostic markers (Ki67, nuclear atypia and mitotic index). Surgical samples of canine oral melanomas will be evaluated and clinically followed-up for a minimum period of 180 days. A primary polyclonal rabbit anti-Galectin-3 antibody will be applied. Proliferative indexes will be determined according to previous studies. Nuclear atypia will be evaluated by computerized morphometric analysis with the aid of software Image ProPlus® and, for statistical analysis, the significance level will be set as 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VARGAS, T. H. M.; PULZ, L. H.; FERRO, D. G.; SOBRAL, R. A.; VENTURINI, M. A. F. A.; CORREA, H. L.; STREFEZZI, R. F.. Galectin-3 Expression Correlates with Post-surgical Survival in Canine Oral Melanomas. Journal of Comparative Pathology, v. 173, p. 49-57, . (13/13252-8, 15/11959-2, 16/03862-1)
VARGAS, THIAGO HENRIQUE M.; BARRA, CAMILA N.; PULZ, LIDIA H.; HUETE, GREICE C.; CADROBBI, KARINE G.; NISHIYA, ADRIANA TOMOKO; KLEEB, SILVIA REGINA; XAVIER, JOSE GUILHERME; CATAO-DIAS, JOSE LUIZ; STREFEZZI, RICARDO F.. Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours. ACTA VETERINARIA HUNGARICA, v. 69, n. 2, p. 169-174, . (13/13252-8, 15/11959-2, 16/03862-1)
LEITE, NATALIA GOULART; MORONI VARGAS, THIAGO HENRIQUE; FERRO, DANIEL GIBERNE; SOBRAL, RENATA AFONSO; FRANCOISE ANITA VENTURINI, MICHELE ALICE; CORREA, HERBERT LIMA; STREFEZZI, RICARDO DE FRANCISCO. Prognostic Value of Intratumoral Collagen Quantification in Canine Oral Melanomas. JOURNAL OF VETERINARY DENTISTRY, . (15/11959-2, 16/03862-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
VARGAS, Thiago Henrique Moroni. Immunohistochemical characterization of Galectin-3 as prognostic tool in canine oral melanomas. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT) Pirassununga.

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