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Multiparameter findings of magnetic resonance in adnexal tumors

Grant number: 15/17670-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Sophie Françoise Mauricette Derchain
Grantee:Ana Carolina Baião Silva
Home Institution: Centro de Atenção Integral à Saúde da Mulher (CAISM). Hospital da Mulher Professor Doutor José Aristodemo Pinotti. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Ovarian cancer corresponds to only 2% of all cancers. In order to detect ovarian cancer on earlier stages, the most utilized exam is ultrasound. However, around 2,7% to 8% of women will have ovarian cysts or pelvic masses, most of them benign. To define the adnexal tumor as benign or malignant, efficient criteria that could be exclusively based at ultrasound aspects or take into account tumor markers, others image exams such as magnetic resonance (MR) and clinical data are needed. The pre-operatory evaluation of adnexal masses contributes to women with malignant neoplasm have appropriate care in reference units and women with benign neoplasm be attended in a conservatory way, with laparoscopy. This study belongs to one research line that evaluates tumor markers and image methods on the discrimination of adnexal masses (Fapesp 2012/15059-8). The pelvic MR is a diagnostic tool available for evaluation of adnexal masses indeterminate by ultrasound. However, current scores of morphological findings, dynamic enhancement pattern by intravenous contrast and diffusion, also named multiparameter, of MR are not validated yet in Brazilian centers, calling attention for the scarcity of national scientific publications. This study aims to identify the multiparameter findings of MR on women with adnexal tumor and their relation with assessment scores already established. It is a cross sectional study. The sample size was calculated 200 women with adnexal tumor, considering 50 malignant tumors, based of obtained accuracy on study by Tomassin-Nagara (2013).The independent variables are: MRdiffusion weighted sequences, morphological aspects of adnexal masses based on Thomassin-Naggara et al (2009) e Timermman et al (2000) studies, subjective evaluation of adnexal injuries and CA 125 serum value. The dependent variable is the result of histological exam. It will be included all women with adnexal tumor that need surgery for definitive diagnosis and/or treatment. Women that did surgery for the treatment of the ovarian mass in another institution will be excluded. All needed information for the study will be registered in an electronic spreadsheet for data collect specifically drawn up for this study. (AU)