Advanced search
Start date

Influence of dichlorvos on the androgen receptor expression in rats prostate subjected chemical inducation by MNU

Grant number: 15/11974-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2016
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Sérgio Pereira
Grantee:Camila Tiemi Hirakawa Quadrado
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Organophosphate pesticides are very effective , widely used , and pose great risk to the environment and health of many organisms , including humans. Dichlorvos (DDVP) is an organophosphate pesticides and these have mutagenic and carcinogenic potential for humans. Many pesticides, such as DDVP, act as endocrine disruptors, may alter endocrine homeostasis. These compounds act via the androgen receptor (AR) or via estrogen receptors (ER) promoting endocrine and reproductive disorders such as prostate cancer. Both androgens and estrogens are closely linked to the control mechanisms of cell proliferation and death that control normal prostate growth, changes in expression and activity of ARs and ERs, are essential for understanding the process of carcinogenesis in the prostate. Thus, the present study aims to evaluate the expression of AR in the rat prostate subjected to chemically induced by MNU associated with pesticide dichlorvos.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list using this form.