Influence of dichlorvos on the androgen receptor expression in rats prostate subjected chemical inducation by MNU

• Grant number: 15/11974-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2015
• Effective date (End): November 30, 2016
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Sérgio Pereira
• Grantee: Camila Tiemi Hirakawa Quadrado
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

Organophosphate pesticides are very effective , widely used , and pose great risk to the environment and health of many organisms , including humans. Dichlorvos (DDVP) is an organophosphate pesticides and these have mutagenic and carcinogenic potential for humans. Many pesticides, such as DDVP, act as endocrine disruptors, may alter endocrine homeostasis. These compounds act via the androgen receptor (AR) or via estrogen receptors (ER) promoting endocrine and reproductive disorders such as prostate cancer. Both androgens and estrogens are closely linked to the control mechanisms of cell proliferation and death that control normal prostate growth, changes in expression and activity of ARs and ERs, are essential for understanding the process of carcinogenesis in the prostate. Thus, the present study aims to evaluate the expression of AR in the rat prostate subjected to chemically induced by MNU associated with pesticide dichlorvos.