| Grant number: |
15/03654-7
|
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): |
December 01, 2015
|
| Effective date (End): |
December 31, 2016
|
| Field of knowledge: | Health Sciences
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Dentistry
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Dental Materials |
|
| Principal Investigator: | Ana Lucia Machado |
| Grantee: | Camila Cristina de Foggi |
|
| Home Institution: |
Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
|
|
Abstract
In the first part of this research project, bimetallic oxides will be synthesized using diferent methods and characterized by X-Ray Diffraction (XRD), Field-Emission Scanning Electron Microscopy (FEG-SEM) and Transmission Electron Microscopy (TEM). Thereafter, the antimicrobial activity of the synthesized compounds against planktonic cells of Methicillin-Resistant Staphylococcus aureus (MRSA) Escherichia coli and Candida albicans will be evaluated by determining the Minimum Inhibitory (MIC) and Minimum Bactericidal/Fungicidal (MBC/MFC) concentrations, as well as growth curve inhibition experiments. Scanning electron microscopy and comet assay will be used to detect possible morphological alterations and DNA damage of C. albicans. In addition, the ability of the synthesized compounds to inhibit the formation of bacterial (MRSA and E. coli) and fungal (C. albicans) biofilms will be evaluated using viable cell counts, total biomass, and scanning electron and confocal laser scanning microscopy analyses. In the second part of the project, the surfaces of denture base acrylic resin specimens will be coated by a Ag-containing plasma polymerized HMDSO film. The adhesion and the biofilm formation of C. albicans on the acrylic surfaces with or without HMDSO film (control) will be evaluated using the viable cell counts, the total biomass, and scanning electron and confocal laser scanning microscopy analyses. When appropriate, data will be analysed by statistical tests, and the results will then be interpreted and discussed. (AU)
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Scientific publications
(6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE FOGGI, CAMILA CRISTINA;
DE OLIVEIRA, REGIANE CRISTINA;
ASSIS, MARCELO;
FABBRO, MARIA TEREZA;
MASTELARO, VALMOR ROBERTO;
VERGANI, CARLOS EDUARDO;
GRACIA, LOURDES;
ANDRES, JUAN;
LONGO, ELSON;
MACHADO, ANA LUCIA.
Unvealing the role of beta-Ag2MoO4 microcrystals to the improvement of antibacterial activity.
Materials Science & Engineering C-Materials for Biological Applications,
v. 111,
JUN 2020.
Web of Science Citations: 0.
HARO CHAVEZ, NATALI LISETTE;
DE AVILA, ERICA DORIGATTI;
BARBUGLI, PAULA ABOUD;
DE OLIVEIRA, REGIANE CRISTINA;
DE FOGGI, CAMILA CRISTINA;
LONGO, ELSON;
VERGANI, CARLOS EDUARDO.
Promising effects of silver tungstate microcrystals on fibroblast human cells and three dimensional collagen matrix models: A novel non-cytotoxic material to fight oral disease.
COLLOIDS AND SURFACES B-BIOINTERFACES,
v. 170,
p. 505-513,
OCT 1 2018.
Web of Science Citations: 3.
DE FOGGI, CAMILA C.;
DE OLIVEIRA, REGIANE C.;
FABBRO, MARIA T.;
VERGANI, CARLOS E.;
ANDRES, JUAN;
LONGO, ELSON;
MACHADO, ANA L.
Tuning the Morphological, Optical, and Antimicrobial Properties of alpha-Ag2WO4 Microcrystals Using Different Solvents.
Crystal Growth & Design,
v. 17,
n. 12,
p. 6239-6246,
DEC 2017.
Web of Science Citations: 4.
FOGGI, CAMILA C.;
FABBRO, MARIA T.;
SANTOS, LUIS P. S.;
DE SANTANA, YURI V. B.;
VERGANI, CARLOS E.;
MACHADO, ANA L.;
CORDONCILLO, ELOISA;
ANDRES, JUAN;
LONGO, ELSON.
Synthesis and evaluation of alpha-Ag2WO4 as novel antifungal agent.
Chemical Physics Letters,
v. 674,
p. 125-129,
APR 16 2017.
Web of Science Citations: 6.
DE OLIVEIRA, REGIANE CRISTINA;
DE FOGGI, CAMILA CRISTINA;
TEIXEIRA, MAYARA MONDEGO;
PENHA DA SILVA, MAYA DAYANA;
ASSIS, MARCELO;
FRANCISCO, ERIC MARK;
ALVES DA SILVA PIMENTEL, BRUNA NATALIA;
DOS SANTOS PEREIRA, PAULA FABIANA;
VERGANI, CARLOS EDUARDO;
MACHADO, ANA LUCIA;
ANDRES, JUAN;
GRACIA, LOURDES;
LONGO, ELSON.
Mechanism of Antibacterial Activity via Morphology Change of alpha-AgVO3: Theoretical and Experimental Insights.
ACS APPLIED MATERIALS & INTERFACES,
v. 9,
n. 13,
p. 11472-11481,
APR 5 2017.
Web of Science Citations: 17.