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Marine pollution's effect on enteric neurons NADH - reactive pufferfish Sphoeroides testudineus (Linnaeus, 1758) (Tetraodontidae)

Grant number: 15/19701-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Renata de Britto Mari
Grantee:Alexandre Rodrigo Nascimento Gonçalves
Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil


The Enteric Nervous System (ENS) is a subdivision of the Autonomic Nervous System consists of a network of neurons and glial cells that are distributed throughout the digestive tract (DT). This neuronal network is divided into two plexuses: the myenteric and submucosal, usually being between the first and second muscular tunics submucosa layer of the TD. The ENS is responsible for the regulation of peristalsis, relaxation and contraction and intestinal excretion chemicals bowel, thus very important for obtaining nutrients and food traffic control in TD. The ENS is present from invertebrates, such as arthropods, even animals more derivatives as mammals, where you can see a morphological diversity between groups, while maintaining the same network standard. In vertebrates, the myenteric plexus is very similar in all groups, varying only in the size of nerve cells, as well as the size of enteric ganglia. Several studies have been conducted to investigate the plasticity of ENS as well as changes across the external agents, such as contaminated food, changes in diet, and disease. Studies aimed at evaluating the effects of contamination on the ENS marine biota are scarce as well, considering that the TD is one of the first environmental contaminants from entering ports external this study aims to analyze which of the effects of marine pollution on the enteric neurons fish, puffer fish if Sphoeroides testudineus. To this end, the two regions will be collected specimens, one represented by the impacted area of São Vicente and a region not impacted represented by the State Ecological Station Juréia-Itatins. After collected and identified 20 examples of puffer fish Sphoeroides testudineus in each region will be collected and intestines intended for histochemistry of NADH-diaphorase technique for marking of myenteric neurons metabolically active. The neurons will be quantified in 60 microscopic fields, measured and the results analyzed by Tukey's test.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO GONCALVES, ALEXANDRE RODRIGO; MARINSEK, GABRIELA PUSTIGLIONE; DE SOUZA ABESSA, DENIS MOLEDO; MARI, RENATA DE BRITTO. Adaptative responses of myenteric neurons of Sphoeroides testudineus to environmental pollution. NeuroToxicology, v. 76, p. 84-92, . (14/07793-9, 15/19701-4)

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