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Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ciprofloxacin with some co-formers

Grant number: 15/19863-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2016
Effective date (End): July 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Flávio Junior Caires
Grantee:Carolina Torquetti
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

This project aims at the synthesis and characterization of solid co-crystals obtained from ciprofloxacin with the co-formers caffeic acid, ferulic acid, p-coumaric acid and chlorogenic acid.The crystals will be obtained through mechanochemical methods (solvent free and/or solvent-assisted grinding), with the aid of a ball mill. The characterization of the co-crystals will be carried out through the following experiments: differential scanning calorimetry (DSC) with microscope system, absorption spectroscopy in the infrared region (FTIR) and X-ray diffraction techniques (powder method and single crystal). It is expected this way to obtain co-crystals capable of promote an improvement in the physico-chemical properties of the antibiotic drug used for this study.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TORQUETTI, CAROLINA; FERREIRA, PATRICIA OSORIO; DE ALMEIDA, AMANDA COSMO; FERNANDES, RICHARD PEROSA; CAIRES, FLAVIO JUNIOR. Thermal study and characterization of new cocrystals of ciprofloxacin with picolinic acid. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, v. 147, n. 2, p. 1299-1306, . (18/24378-6, 17/14936-9, 13/09022-7, 15/19863-4)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.