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Label Free Electrochemical Multiplexing Prostate Cancer Diagnostics

Grant number: 15/17332-1
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2016
Effective date (End): March 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Paulo Roberto Bueno
Grantee:Beatriz Lucas Garrote
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:12/22820-7 - The sensitive label free detection of disease markers using electrochemical immittance, AP.TEM


Prostate cancer (PCa) is a commonly diagnosed cancer among men around the world. The detection of PCain early stages can help clinicians to administer an effective and preventive treatment. For this purpose, theaim of this project is the development of a sensitive, portable, cheap and multiplexable biosensor. This is alabel-free electrochemical multiplexing assay which has specific electrode-immobilised biomarkers (PAP,fPSA and tPSA) for the premature diagnostic of prostate cancer. Label-free detection has many advantagesover the labelled techniques as the quicker protocols, reducing the background signal and higher levels ofsensitivity. Our biosensor is based in impedance/capacitance measurements of the electrode-solutioninterface. If there is interaction between the target analyte in the sample and the electrode-immobilisedbiomarker, the measure will change detectably.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GARROTE, Beatriz Lucas. The potentiality and limitations of electrochemical impedance spectroscopic methods for molecular film applications. 2018. 75 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Química..

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