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Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring

Grant number: 14/22313-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2016
Effective date (End): March 31, 2019
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:José Cipolla Neto
Grantee:Lívia Clemente Motta Teixeira
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo, SP, Brazil
Associated research grant:14/50457-0 - Melatonin and the control of energy metabolism: basic, clinical and epidemiological research, AP.TEM
Associated scholarship(s):16/18941-4 - Effects of maternal melatonin deprivation during pregnancy and lactation on the offspring neuroimmune system, BE.EP.DR


Shift  work is a widespread practice in our society, which is detrimental to the health of workers. These impairments may be associated with changes in melatonin synthesis, which plays a role in the regulation of energy metabolism and neurogenesis functions. It is known that melatonin is a hormone that has been shown to be essential in intrauterine programming and immediate post-natal as well as being of fundamental importance in the expression of neural plastic processes. Thus it is possible that neurogenic changes occurs in response to the absence of maternal melatonin during pregnancy and / or lactation leading, knowingly, to metabolic disorders in the offspring and the possible neurogenic changes, whether induced directly, are mediated by metabolic disorders.In this proposal we aim to to evaluate whether hippocampal and hypothalamic neurogenesis is disturbed by the absence of melatonin during pregnancy and lactation and / or the metabolic dysfunction cause.In adition, evaluate possible changes the somatic and neurological development of the offspring.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KUMAR, AMRITA JHA; MOTTA-TEIXEIRA, LIVIA CLEMENTE; TAKADA, SILVIA HONDA; YONAMINE-LEE, VITOR; MACHADO-NILS, ALINE VILAR; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES. Behavioral, cognitive and histological changes following neonatal anoxia: Male and female rats' differences at adolescent age. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 73, p. 50-58, APR 2019. Web of Science Citations: 0.
MOTTA-TEIXEIRA, LIVIA CLEMENTE; MACHADO-NILS, ALINE VILAR; BATTAGELLO, DANIELLA SABINO; DINIZ, GIOVANNE BARONI; ANDRADE-SILVA, JESSICA; SILVA JR, SINESIO; MATOS, RAPHAEL AFONSO; DO AMARAL, FERNANDA GASPAR; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI; REITER, RUSSEL J.; LUCASSEN, PAUL JOHN; KOROSI, ANIKO; CIPOLLA-NETO, JOSE. The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, v. 105, p. 146-156, SEP 2018. Web of Science Citations: 1.
KUMAR, AMRITA JHA; TAKADA, SILVIA HONDA; MOTTA-TEIXEIR, LIVIA CLEMENTE; LEE, VITOR YONAMINE; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES. Sex differences in somatic and sensory motor development after neonatal anoxia in Wistar rats. Behavioural Brain Research, v. 333, p. 242-250, AUG 30 2017. Web of Science Citations: 1.

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