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The role of miRNAs 143 and 164a variants in prostate cancer

Grant number: 15/23248-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Sabrina Thalita dos Reis Faria
Grantee:Gabriel Fernandes Dias Ferreira
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Prostate cancer is the second major cause of death by cancer in Brazil. Currently, population screening methods and prognostic exams used in Brazil (PSA levels and digital rectal exam) are being questioned for their reliability, so the search for a genetic predictor of prostate cancer development risk and prognostic definition became imperative. Two microRNAs - miR-143 and miR-164a - were identified as tumor suppressors in the prostate cancer and recently variations were found on the promoter region of these miRNAs (rs4705342; rs2910164). The objective of our study is to identify the role of these variants on the development and prognostic of prostate cancer. DNA samples from 200 patients (100 patients diagnosed with prostate cancer and 100 patients without prostate cancer, as a control group) will be used. The identification of the polymorphisms will be perform through real-time PCR.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CAMARGO, JULIANA ALVES; LOPES, RENAN EBOLI; FERREIRA, GABRIEL FERNANDES DIAS; VIANA, NAYARA IZABEL; GUIMARAES, VANESSA; LEITE, KATIA RAMOS MOREIRA; NAHAS, WILLIAM C.; SROUGI, MIGUEL; ANTUNES, ALBERTO A.; REIS, SABRINA T.. The role of single nucleotide polymorphisms of miRNAs 100 and 146a as prognostic factors for prostate cancer. International Journal of Biological Markers, v. 36, n. 2, p. 50-56, . (15/23248-3)

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