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Performance of bioglass/collagen/magnesium composites in bone repair of rats

Grant number: 15/20704-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2016
Effective date (End): February 29, 2020
Field of knowledge:Interdisciplinary Subjects
Principal researcher:Ana Claudia Muniz Renno
Grantee:Paulo Roberto Gabbai Armelin
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Associated scholarship(s):18/16328-9 - Characterization and in vitro investigations of growth factor-enriched biosilica for bone repair, BE.EP.PD


During bone repair, approximately in 10% of the cases can occur an abnormal bone consolidation, and consequently, culminate in nonunion fractures. These events may affect the life quality of the patients, leading to high morbidity and mortality rates, as well as, high financial costs. So, it is necessary to utilize therapeutic approaches which allow the osteoinduction and osteoconduction. Among these approaches, the bioglass is in evidence, since this material can induce and accelerate the bone repair. In order to optimize the performance of the bioglass, it is suggested its combination with collagen and magnesium, mimicking the natural bone tissue. Thus, the present study can be divided into three main points: (i) characterize the bioglass/collagen/magnesium composites. (ii) Evaluate the biocompatibility of these composites through in vitro studies using cytotoxicity and genotoxicity assays. Based on the in vitro studies, it will be defined the more adequate proportion of magnesium (1, 3 ou 5%) combined with bioglass and collagen. After defining the magnesium proportion, this study aims at (iii) evaluating, via in vivo studies, the effect of these composites on the bone repair of tibial defects in rats. Toward the achievement of these objectives, firstly, the composites will be characterize using physico-chemical evaluations. Moreover, the composites will be tested by cell culture assays in order to verify the citotoxicity, genotoxicity, cellular proliferation and gene expression. After these procedures, in vivo evaluation will be performed such as micro-CT, histopathological analysis, morphometry, immunohistochemistry and biomechanical tests. It is hypothesized that the development of this project will result in socio-economic benefits for the Brazilian population, since the investigation of the biological performance of bioglass/collagen/magnesium composites may lead to development of more effective and safe treatments for health care.

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MATHEUS DE ALMEIDA CRUZ; PAULO ROBERTO GABBAI-ARMELIN; ALAN DE FRANÇA SANTANA; JOÃO PAULO DOS SANTOS PRADO; INGRID REGINA AVANZI; JULIA RISSO PARISI; MÁRCIO REIS CUSTÓDIO; RENATA NEVES GRANITO; ANA CLAUDIA MUNIZ RENNO. In Vivo Biological Effects of Marine Biosilica on a Tibial Bone Defect in Rats. Brazilian Archives of Biology and Technology, v. 63, p. -, 2020. Web of Science Citations: 0.
GABBAI-ARMELIN, PAULO ROBERTO; KIDO, HUELITON WILIAN; FERNANDES, KELLY ROSSETTI; FORTULAN, CARLOS ALBERTO; MUNIZ RENNO, ANA CLAUDIA. Effects of bio-inspired bioglass/collagen/magnesium composites on bone repair. JOURNAL OF BIOMATERIALS APPLICATIONS, v. 34, n. 2, p. 261-272, AUG 2019. Web of Science Citations: 1.
GABBAI-ARMELIN, P. R.; FERNANDES, K. R.; MAGRI, A. M. P.; DA SILVA, A. C.; FORTULAN, C. A.; RENNO, A. C. M. Characterization and cytotoxicity evaluation of bio-inspired bioactive Glass/Collagen/Magnesium composites. Materials Chemistry and Physics, v. 228, p. 201-209, APR 15 2019. Web of Science Citations: 0.
GABBAI-ARMELIN, P. R.; KIDO, H. W.; CRUZ, M. A.; PRADO, J. P. S.; AVANZI, I. R.; CUSTODIO, M. R.; RENNO, A. C. M.; GRANITO, R. N. Characterization and Cytotoxicity Evaluation of a Marine Sponge Biosilica. MARINE BIOTECHNOLOGY, v. 21, n. 1, p. 65-75, FEB 2019. Web of Science Citations: 1.
VAN HOUDT, CLAIRE I. A.; GABBAI-ARMELIN, PAULO R.; LOPEZ-PEREZ, PAULA M.; ULRICH, DIETMAR J. O.; JANSEN, JOHN A.; RENNO, ANA CLAUDIA M.; VAN DEN BEUCKEN, JEROEN J. J. P. Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions. SCIENTIFIC REPORTS, v. 8, OCT 18 2018. Web of Science Citations: 1.
GABBAI-ARMELIN, PAULO R.; RENNO, ANA C. M.; CROVACE, MURILO C.; MAGRI, ANGELA M. P.; ZANOTTO, EDGAR D.; PEITL, OSCAR; LEEUWENBURGH, SANDER C. G.; JANSEN, JOHN A.; VAN DEN BEUCKEN, JEROEN J. J. P. Putty-like bone fillers based on CaP ceramics or Biosilicate (R) combined with carboxymethylcellulose: Characterization, optimization, and evaluation. JOURNAL OF BIOMATERIALS APPLICATIONS, v. 32, n. 2, p. 276-288, AUG 2017. Web of Science Citations: 1.

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