Influence of Spondias mombin supplementation on the cardiac remodeling after acute myocardial infarction

• Grant number: 14/23215-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): March 01, 2016
• Effective date (End): February 28, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Marcos Ferreira Minicucci
• Grantee: Bruna Letícia Buzati Pereira
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated scholarship(s): 18/03082-1 - The effects of common bean-supplemented diets on gut health, the microbiome and obesity-associated inflammation in mice, BE.EP.DR

Abstract

Cardiovascular diseases are the major cause of death in the world and it is estimated that, in 2030, they will be responsible for approximately 23.6 million deaths. Among cardiovascular diseases, we can highlight acute coronary syndromes, especially acute myocardial infarction (AMI). Heart failure is a frequent complication after the AMI and several factors influence its development, one of these factors is cardiac remodeling. The increase oxidative stress and inflammation process are associated with cardiac remodeling after the AMI. Due to the great economic and social impact and the high mortality rates, it is important to identify other factors that attenuate cardiac remodeling process. Among these factors are the food supplementation with antioxidant properties, such as Spondias mombin (SM). It is believed that the beneficial effects are attributed to the phenolic compounds, flavonoids and carotenoids present in the fruit. One study evaluated the administration of SM in a myocardial injury induced by isoproterenol and observed increased activity of superoxide dismutase and catalase and decreased concentrations of glutathione and malondealdeído. However, the SM influence on cardiac remodeling after the AMI has not been studied yet.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BUZATI PEREIRA, BRUNA LETICIA; RODRIGUE, ALEXANE; DE OLIVEIRA ARRUDA, FERNANDA CAROLINE; BACHIEGA, TATIANA FERNANDA; MARTINS LOURENCO, MARIA ANGELICA; CORREA, CAMILA RENATA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; OKOSHI, KATASHI; HENRIQUE FERNANDES, ANA ANGELICA; et al. Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, MAY 2020. (15/18502-8, 14/23215-5, 18/03082-1)

BUZATI PEREIRA, BRUNA LETICIA; RODRIGUE, ALEXANE; DE OLIVEIRA ARRUDA, FERNANDA CAROLINE; BACHIEGA, TATIANA FERNANDA; MARTINS LOURENCO, MARIA ANGELICA; CORREA, CAMILA RENATA; AZEVEDO, PAULA SCHMIDT; POLEGATO, BERTHA FURLAN; OKOSHI, KATASHI; HENRIQUE FERNANDES, ANA ANGELICA; et al. Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress and inflammatory modulation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v. 24, n. 14, p. 7862-7872, JUL 2020. (18/03082-1, 15/18502-8, 14/23215-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PEREIRA, Bruna Letícia Buzati. Influence of Spondias mombin L. supplementation on cardiac remodeling after acute myocardial infarction. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.