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DISCOVERY AND VERIFICATION OF INTACT GLYCOPEPTIDES AS CANDIDATE PROSTATE CANCER BIOMARKERS USING MASS SPECTROMETRY-BASED PROTEOMICS APPROACHES

Grant number: 15/02866-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2016
Effective date (End): July 07, 2019
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Giuseppe Palmisano
Grantee:Rebeca Kawahara Sakuma
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications, AP.JP
Associated scholarship(s):17/03010-8 - Site-specific characterization of N- and O-linked glycosylation in prostate cancer tissues as molecular signature for disease progression, BE.EP.PD

Abstract

Prostate cancer (PCa) is the second most frequently diagnosed cancer in Brazil. Serum prostate specific antigen (PSA) is currently used for early detection of prostate cancer, however it lacks in specificity especially in Benign Prostatic Hyperplasia (BPH). Besides, it has limited accuracy to determine poor prognosis or drug resistance conditions. A growing body of evidence supports crucial roles for glycoproteins at various pathophysiological steps of tumor progression, including proliferation, invasion, metastasis, angiogenesis and drug resistance. It has been demonstrated that not only the levels of glycoproteins are altered in malignant conditions but also the glycosylation patterns. Therefore, the quantification of different glycoforms can improve the biomarker potential of these glycoproteins. This project aims to identify a panel of intact glycopeptides differentially expressed in urines from control and prostate cancer patients. For that, mass spectrometry-based proteomics approaches will be used for both discovery as well as verification of the candidate glycopeptides biomarkers. With this project, we want to improve the understanding of glycosylation in cancer and present a novel strategy for discovery and verification of candidate glycopeptide biomarkers more specific in prostate cancer.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KAWAHARA, REBECA; RECUERO, SAULO; SROUGI, MIGUEL; LEITE, KATIA R. M.; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. The Complexity and Dynamics of the Tissue Glycoproteome Associated With Prostate Cancer Progression. MOLECULAR & CELLULAR PROTEOMICS, v. 20, 2021. Web of Science Citations: 3.
CHATTERJEE, SAYANTANI; LEE, LING Y.; KAWAHARA, REBECA; ABRAHAMS, JODIE L.; ADAMCZYK, BARBARA; ANUGRAHAM, MERRINA; ASHWOOD, CHRISTOPHER; SUMER-BAYRAKTAR, ZEYNEP; BRIGGS, MATTHEW T.; CHIK, JENNY H. L.; EVEREST-DASS, ARUN; FOERSTER, SARAH; HINNEBURG, HANNES; LEITE, KATIA R. M.; LOKE, IAN; MOGINGER, UWE; MOH, EDWARD S. X.; NAKANO, MIYAKO; RECUERO, SAULO; SETHI, MANVEEN K.; SROUGI, MIGUEL; STAVENHAGEN, KATHRIN; VENKATAKRISHNAN, VIGNESH; WONGTRAKUL-KISH, KATHERINE; DIESTEL, SIMONE; HOFFMANN, PETER; KARLSSON, NICLAS G.; KOLARICH, DANIEL; MOLLOY, MARK P.; MUDERS, MICHAEL H.; OEHLER, MARTIN K.; PACKER, NICOLLE H.; PALMISANO, GIUSEPPE; THAYSEN-ANDERSEN, MORTEN. Protein Paucimannosylation Is an Enriched N-Glycosylation Signature of Human Cancers. PROTEOMICS, v. 19, n. 21-22, SI NOV 2019. Web of Science Citations: 2.
KAWAHARA, REBECA; RECUERO, SAULO; NOGUEIRA, FABIO C. S.; DOMONT, GILBERTO B.; LEITE, KATIA R. M.; SROUGI, MIGUEL; THAYSEN-ANDERSEN, MORTEN; PALMISANO, GIUSEPPE. Tissue Proteome Signatures Associated with Five Grades of Prostate Cancer and Benign Prostatic Hyperplasia. PROTEOMICS, v. 19, n. 21-22, SI NOV 2019. Web of Science Citations: 0.
ROSA-FERNANDES, LIVIA; CUGOLA, FERNANDA RODRIGUES; RUSSO, FABIELE BALDINO; KAWAHARA, REBECA; DE MELO FREIRE, CAIO CESAR; CORREA LEITE, PAULO EMLIO; BASSI STERN, ANA CAROLINA; ANGELI, CLAUDIA BLANES; LEAL DE OLIVEIRA, DANIELLE BRUNA; MELO, STELLA REZENDE; DE ANDRADE ZANOTTO, PAOLO MARINHO; DURIGON, EDISON LUIZ; LARSEN, MARTIN ROSSEL; BALEEIRO BELTRAO-BRAGA, PATRICIA CRISTINA; PALMISANO, GIUSEPPE. Zika Virus Impairs Neurogenesis and Synaptogenesis Pathways in Human Neural Stem Cells and Neurons. FRONTIERS IN CELLULAR NEUROSCIENCE, v. 13, MAR 15 2019. Web of Science Citations: 1.
DE OLIVEIRA, GILBERTO SANTOS; KAWAHARA, REBECA; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; AVILA, CARLA CRISTI; TEIXEIRA, MARTA M. G.; LARSEN, MARTIN R.; PALMISANO, GIUSEPPE. Development of a Trypanosoma cruzi strain typing assay using MS2 peptide spectral libraries (Tc-STAMS2). PLoS Neglected Tropical Diseases, v. 12, n. 4 APR 2018. Web of Science Citations: 3.
DE OLIVEIRA, GILBERTO SANTOS; KAWAHARA, REBECA; ROSA-FERNANDES, LIVIA; AVILA, CARLA C.; LARSEN, MARTIN R.; PEREIRA ALVES, JOAO MARCELO; PALMISANO, GIUSEPPE. Novel DNA coding regions and protein arginylation reveal unexplored T. cruzi proteome and PTMs. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, n. SI, p. 51-66, JUL 2017. Web of Science Citations: 1.
KAWAHARA, REBECA; SAAD, JOYCE; ANGELI, CLAUDIA BLANES; PALMISANO, GIUSEPPE. Site-specific characterization of N-linked glycosylation in human urinary glycoproteins and endogenous glycopeptides. GLYCOCONJUGATE JOURNAL, v. 33, n. 6, p. 937-951, DEC 2016. Web of Science Citations: 5.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.