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Inter-organ communication between BAT and muscle: role of batokines in whole body energy homeostasis

Grant number: 16/03682-3
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): June 20, 2016
Effective date (End): June 19, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Leonardo dos Reis Silveira
Grantee:Carlos Henrique Grossi Sponton
Supervisor abroad: Shingo Kajimura
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Local de pesquisa : University of California, San Francisco (UCSF), United States  
Associated to the scholarship:14/14170-8 - The cellular signalling mediated by exosomes: a new paradigm in the control of mitochondrial function and insulin response in primary skeletal muscle cells, BP.PD

Abstract

Brown (BAT) and beige adipose cells have the capacity to produce heat (thermogenesis) due to substrate oxidation. This futile cycle is essentially regulated by the action of uncoupling protein 1 (UCP1), a protein located in the inner mitochondrial membrane of brown and beige adipocytes 1. The thermogenesis program is considered a valuable tool to counteract metabolic diseases such as obesity and diabetes. Studies suggest that biological significance of beige adipocytes may overcome simply generating heat in response to stress stimulus 2. Since white adipose tissue (WAT) secrete many adipokines, it is not unrealistic to consider that brown and beige fat cells might secrete molecules to act local or systemically modulating the metabolism. In this line, the transplantation of the inguinal WAT depots from exercised mice improves various aspects of glucose homeostasis much more than equivalent fat transplantations from sedentary mice 3. In addition, Swensson and colleagues demonstrated that brown adipose tissue release a functional cleaved C-terminal fragment (Slit2-C) in plasma that promotes thermogenic program in WAT and systemic improvements of glucose homeostasis in mice 4. While a major function of brown and beige fat is thermogenesis, recent studies from Kajimura lab and others suggest that BAT is not simply a heat-generating organ, but also function as an endocrine organ via BAT-derived secretory molecules, as referred to as "batokines". My work will aim to characterize batokines that mediate the inter-organ communication between BAT and skeletal muscle in the context of exercise and cold exposure.

Articles published in other media outlets (28 total):
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Correio Popular (Campinas, SP): Pesquisa fornece dados inéditos da função do tecido adiposo marrom (24/Mar/2021)
Estadão.com: Proteína secretada pela própria gordura do corpo pode ajudar a emagrecer? (22/Feb/2021)
UOL: Proteína produzida por tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
Correio Popular (Campinas, SP) online: Pesquisa traz dados inéditos para tratar doenças crônicas (24/Mar/2021)
O Popular (Mogi Mirim, SP) online: Triunfo para a perda de peso (05/Mar/2021)
NewsBeezer: A perda de peso pode ficar mais fácil com a ajuda de proteínas (26/Feb/2021)
newsdol.com: A perda de peso pode ser facilitada com a ajuda de proteínas (26/Feb/2021)
O Popular (Mogi Mirim, SP): Trunfo para perda de peso (26/Feb/2021)
Coluna Supinando: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (25/Feb/2021)
Diário da Saúde: Proteína da gordura marrom pode facilitar a perda de peso (23/Feb/2021)
Plantão News (MT): Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (23/Feb/2021)
LabNetwork: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (23/Feb/2021)
Panorama Farmacêutico: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (23/Feb/2021)
Razões para Acreditar: Proteína pode facilitar a perda de peso e o controle da glicose, aponta estudo (23/Feb/2021)
SaveDelete (Índia): Can Protein Secreted by Body’s Fat help lose Weight? (23/Feb/2021)
Terra: Proteína secretada pela própria gordura do corpo pode ajudar a emagrecer? (22/Feb/2021)
Meio Norte online (Piauí): Proteína produzida pelo tecido adiposo marrom facilita a perda de peso (22/Feb/2021)
UNICAMP - Universidade Estadual de Campinas: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
MSN: Proteína secretada pela própria gordura do corpo pode ajudar a emagrecer? (22/Feb/2021)
Revista Amazônia: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
A Crítica (AM) online: Proteína produzida pelo tecido adiposo marrom facilita a perda de peso (22/Feb/2021)
Atemporal: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
Diário do Pará online: Proteína pode facilitar perda de peso e melhorar controle da glicose (22/Feb/2021)
Saense: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
Portal da Enfermagem: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
Belém online: Proteína pode facilitar perda de peso e melhorar controle da glicose (22/Feb/2021)
FOCEP Brasil: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)
Novo Cantu Notícias: Proteína produzida pelo tecido adiposo marrom pode facilitar a perda de peso (22/Feb/2021)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SPONTON, CARLOS H.; HOSONO, TAKASHI; TAURA, JUNKI; JEDRYCHOWSKI, MARK P.; YONESHIRO, TAKESHI; WANG, QIANG; TAKAHASHI, MAKOTO; MATSUI, YUMI; IKEDA, KENJI; OGURI, YASUO; TAJIMA, KAZUKI; SHINODA, KOSAKU; PRADHAN, RACHANA N.; CHEN, YONG; BROWN, ZACHARY; ROBERTS, LINDSAY S.; WARD, CARL C.; TAOKA, HIROKI; YOKOYAMA, YOKO; WATANABE, MITSUHIRO; KARASAWA, HIROSHI; NOMURA, DANIEL K.; KAJIMURA, SHINGO. The regulation of glucose and lipid homeostasis viaPLTPas a mediator ofBAT-liver communication. EMBO REPORTS, JUL 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.