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Frequencies of single nucleotide polymorphisms (SNPs) near the IL28B gene in HIV-1-infected patients and in patients coinfected with HIV-1/HTLV-1, HIV-1/HTLV-2 and HIV-1/HCV

Grant number: 16/01666-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Adele Caterino de Araújo
Grantee:Bruna Viscardi Azevedo
Home Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Single nucleotide polymorphisms (SNPs, rs12979860 e rs8099917) near the IL28B gene responsible for the production of interferon lambda (IFN ») have been associated with failure in antiviral innate immunity, treatment with PEG-IFN± and ribavirin and sustained virological response in hepatitis C. These polymorphisms have been studied in human T-lymphotropic virus (HTLV-1) infected individuals and have been associated with asymptomatic carrier or tropical spastic paraparesis/myelopathy associated with HTLV-1 (TSP/HAM) cases. The present study has the aim to investigate the frequency rates of polymorphisms in such SNPs in HIV-1-infected patients and in patients coinfected with HIV/HTLV-1, HIV/HTLV-2 and HIV/HCV, using the PCR-RFLP assays optimized in the HTLV Laboratory of Instituto Adolfo Lutz in São Paulo. Blood samples of 500 patients seen at an STD/AIDS Reference Center in São Paulo will be analyzed after signed informed consent. Differences in the results obtained in each group of patient could be used in the future as prognostic marker in predicting diseases and treatment outcomes in such patients.